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MeSH Review

Iron Overload

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Disease relevance of Iron Overload


Psychiatry related information on Iron Overload


High impact information on Iron Overload

  • Individuals with hereditary hemochromatosis suffer from systemic iron overload due to duodenal hyperabsorption [8].
  • Although expression of mouse Hamp is normally greater during iron overload, Hfe-/- mice have inappropriately low expression of Hamp [9].
  • Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis [9].
  • Deferiprone in iron overload [10].
  • To examine the hypothesis that African iron overload also involves a genetic factor, we used likelihood analysis to test for an interaction between a gene (the hypothesized iron-loading locus) and an environmental factor (increased dietary iron) that determines transferrin saturation and unsaturated iron-binding capacity [11].

Chemical compound and disease context of Iron Overload


Biological context of Iron Overload


Anatomical context of Iron Overload


Gene context of Iron Overload


Analytical, diagnostic and therapeutic context of Iron Overload


  1. Iron-chelation therapy with oral deferipronein patients with thalassemia major. Olivieri, N.F., Brittenham, G.M., Matsui, D., Berkovitch, M., Blendis, L.M., Cameron, R.G., McClelland, R.A., Liu, P.P., Templeton, D.M., Koren, G. N. Engl. J. Med. (1995) [Pubmed]
  2. Prevention of cardiac disease by subcutaneous deferoxamine in patients with thalassemia major. Wolfe, L., Olivieri, N., Sallan, D., Colan, S., Rose, V., Propper, R., Freedman, M.H., Nathan, D.G. N. Engl. J. Med. (1985) [Pubmed]
  3. Crystal structure of the hemochromatosis protein HFE and characterization of its interaction with transferrin receptor. Lebrón, J.A., Bennett, M.J., Vaughn, D.E., Chirino, A.J., Snow, P.M., Mintier, G.A., Feder, J.N., Bjorkman, P.J. Cell (1998) [Pubmed]
  4. Diagnostic efficacy of hepatic computed tomography in the detection of body iron overload. Howard, J.M., Ghent, C.N., Carey, L.S., Flanagan, P.R., Valberg, L.S. Gastroenterology (1983) [Pubmed]
  5. Prevention of hepatitis C virus-related hepatocellular carcinoma. Heathcote, E.J. Gastroenterology (2004) [Pubmed]
  6. Patient compliance with phlebotomy therapy for iron overload associated with hemochromatosis. Hicken, B.L., Tucker, D.C., Barton, J.C. Am. J. Gastroenterol. (2003) [Pubmed]
  7. Ascorbic acid deficiency, iron overload and alcohol abuse underlie the severe osteoporosis in black African patients with hip fractures--a bone histomorphometric study. Schnitzler, C.M., Schnaid, E., MacPhail, A.P., Mesquita, J.M., Robson, H.J. Calcif. Tissue Int. (2005) [Pubmed]
  8. Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis. Muckenthaler, M., Roy, C.N., Custodio, A.O., Miñana, B., deGraaf, J., Montross, L.K., Andrews, N.C., Hentze, M.W. Nat. Genet. (2003) [Pubmed]
  9. Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis. Nicolas, G., Viatte, L., Lou, D.Q., Bennoun, M., Beaumont, C., Kahn, A., Andrews, N.C., Vaulont, S. Nat. Genet. (2003) [Pubmed]
  10. Deferiprone in iron overload. Hoffbrand, A.V., Wonke, B. N. Engl. J. Med. (1995) [Pubmed]
  11. Iron overload in Africa. Interaction between a gene and dietary iron content. Gordeuk, V., Mukiibi, J., Hasstedt, S.J., Samowitz, W., Edwards, C.Q., West, G., Ndambire, S., Emmanual, J., Nkanza, N., Chapanduka, Z. N. Engl. J. Med. (1992) [Pubmed]
  12. Intravenous or subcutaneous deferoxamine for iron overload? Kramer, P. N. Engl. J. Med. (1978) [Pubmed]
  13. Vitamin C and iron overload. Herbert, V. N. Engl. J. Med. (1981) [Pubmed]
  14. 2,3-DHB ineffective in treatment of iron overload. Peterson, C.M., Grady, R.W., Jones, R.L., Cerami, A., Graziano, J.H., Markenson, A.L., Lavi, U., Canale, V., Gray, G.F., Miller, D.R. N. Engl. J. Med. (1977) [Pubmed]
  15. L-type Ca2+ channels provide a major pathway for iron entry into cardiomyocytes in iron-overload cardiomyopathy. Oudit, G.Y., Sun, H., Trivieri, M.G., Koch, S.E., Dawood, F., Ackerley, C., Yazdanpanah, M., Wilson, G.J., Schwartz, A., Liu, P.P., Backx, P.H. Nat. Med. (2003) [Pubmed]
  16. The evolution of iron chelators for the treatment of iron overload disease and cancer. Kalinowski, D.S., Richardson, D.R. Pharmacol. Rev. (2005) [Pubmed]
  17. Ca2+ channel blockers reverse iron overload by a new mechanism via divalent metal transporter-1. Ludwiczek, S., Theurl, I., Muckenthaler, M.U., Jakab, M., Mair, S.M., Theurl, M., Kiss, J., Paulmichl, M., Hentze, M.W., Ritter, M., Weiss, G. Nat. Med. (2007) [Pubmed]
  18. Crystal structure of the hereditary haemochromatosis protein HFE complexed with transferrin receptor. Bennett, M.J., Lebrón, J.A., Bjorkman, P.J. Nature (2000) [Pubmed]
  19. A mouse model of juvenile hemochromatosis. Huang, F.W., Pinkus, J.L., Pinkus, G.S., Fleming, M.D., Andrews, N.C. J. Clin. Invest. (2005) [Pubmed]
  20. Phenotypic expression of HFE mutations: a French study of 1110 unrelated iron-overloaded patients and relatives. Moirand, R., Jouanolle, A.M., Brissot, P., Le Gall, J.Y., David, V., Deugnier, Y. Gastroenterology (1999) [Pubmed]
  21. Duodenal expression of a putative stimulator of Fe transport and transferrin receptor in anemia and hemochromatosis. Barisani, D., Parafioriti, A., Armiraglio, E., Meneveri, R., Conte, D. Gastroenterology (2001) [Pubmed]
  22. Alterations in the structure, physicochemical properties, and pH of hepatocyte lysosomes in experimental iron overload. Myers, B.M., Prendergast, F.G., Holman, R., Kuntz, S.M., LaRusso, N.F. J. Clin. Invest. (1991) [Pubmed]
  23. Differential expression of transferrin receptor in duodenal mucosa in iron overload. Evidence for a site-specific defect in genetic hemochromatosis. Lombard, M., Bomford, A.B., Polson, R.J., Bellingham, A.J., Williams, R. Gastroenterology (1990) [Pubmed]
  24. Expression of the duodenal iron transporters divalent-metal transporter 1 and ferroportin 1 in iron deficiency and iron overload. Zoller, H., Koch, R.O., Theurl, I., Obrist, P., Pietrangelo, A., Montosi, G., Haile, D.J., Vogel, W., Weiss, G. Gastroenterology (2001) [Pubmed]
  25. Correction of the iron overload defect in beta-2-microglobulin knockout mice by lactoferrin abolishes their increased susceptibility to tuberculosis. Schaible, U.E., Collins, H.L., Priem, F., Kaufmann, S.H. J. Exp. Med. (2002) [Pubmed]
  26. Prevalence of genetic hemochromatosis in a cohort of Italian patients with diabetes mellitus. Conte, D., Manachino, D., Colli, A., Guala, A., Aimo, G., Andreoletti, M., Corsetti, M., Fraquelli, M. Ann. Intern. Med. (1998) [Pubmed]
  27. Targeted mutagenesis of the murine transferrin receptor-2 gene produces hemochromatosis. Fleming, R.E., Ahmann, J.R., Migas, M.C., Waheed, A., Koeffler, H.P., Kawabata, H., Britton, R.S., Bacon, B.R., Sly, W.S. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  28. GRACILE syndrome, a lethal metabolic disorder with iron overload, is caused by a point mutation in BCS1L. Visapää, I., Fellman, V., Vesa, J., Dasvarma, A., Hutton, J.L., Kumar, V., Payne, G.S., Makarow, M., Van Coster, R., Taylor, R.W., Turnbull, D.M., Suomalainen, A., Peltonen, L. Am. J. Hum. Genet. (2002) [Pubmed]
  29. Reassessment of the use of desferrioxamine B in iron overload. Propper, R.D., Shurin, S.B., Nathan, D.G. N. Engl. J. Med. (1976) [Pubmed]
  30. Diagnosis of hemochromatosis in young subjects: predictive accuracy of biochemical screening tests. Bassett, M.L., Halliday, J.W., Ferris, R.A., Powell, L.W. Gastroenterology (1984) [Pubmed]
  31. Survival after liver transplantation in patients with hepatic iron overload: the national hemochromatosis transplant registry. Kowdley, K.V., Brandhagen, D.J., Gish, R.G., Bass, N.M., Weinstein, J., Schilsky, M.L., Fontana, R.J., McCashland, T., Cotler, S.J., Bacon, B.R., Keeffe, E.B., Gordon, F., Polissar, N. Gastroenterology (2005) [Pubmed]
  32. Management of hemochromatosis. Hemochromatosis Management Working Group. Barton, J.C., McDonnell, S.M., Adams, P.C., Brissot, P., Powell, L.W., Edwards, C.Q., Cook, J.D., Kowdley, K.V. Ann. Intern. Med. (1998) [Pubmed]
  33. The effect of chelating agents on iron mobilization in Chang cell cultures. White, G.P., Jacobs, A., Grady, R.W., Cerami, A. Blood (1976) [Pubmed]
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