Inhibition of erythrocyte sickling in vitro by DL-glyceraldehyde.
Concentrations of DL-glyceraldehyde between 5 and 20 mM reduce the sickling of S/S erythrocytes even in the complete absence of oxygen; at 10 mM glyceraldehyde the increase in the number of normal cells ranges from 20 to 40%. The inhibition of sickling was both concentration- and time-dependent and was not reversed by repeated washings with buffer. Incubation of erythrocytes with increasing concentrations of glyceraldehyde resulted in only a small increase in the oxygen affinity, a moderate reduction in the Hill coefficient, a substantial increase in the minimum gelling concentration, and modification of up to two lysine residues per hemoglobin molecule.[1]References
- Inhibition of erythrocyte sickling in vitro by DL-glyceraldehyde. Nigen, A.M., Manning, J.M. Proc. Natl. Acad. Sci. U.S.A. (1977) [Pubmed]
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