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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Tumor promoters inhibit spontaneous differentiation of Friend erythroleukemia cells in culture.

Clones of Friend erythroleukemia cells, characterized by the presence of 40-70% benzidine-positive cells synthesizing hemoglobin in the absence of inducing drugs, were treated with several phorbol diesters with a known range of tumor-promoting activity on mouse skin. Good correlation was found between the reported tumor-promoting activity of a particular phorbol diester and its ability to inhibit spontaneous erythroid differentiation in culture. The inhibition of differentiation by 12-O-tetradecanoyl-phorbol-13-acetate, the most active tumor promoter, was maximum after 4 days of treatment; this inhibition was reversed by removal of the phorbol diester no matter how long the period of treatment. Unlike control cells, which gradually revert to a population with a low percentage of benzidine-positive cells, cells treated with 12-O-tetradecanoyl-phorbol-13-acetate retained a high potential for spontaneous differentiation.[1]


  1. Tumor promoters inhibit spontaneous differentiation of Friend erythroleukemia cells in culture. Rovera, G., O'Brien, T.G., Diamond, L. Proc. Natl. Acad. Sci. U.S.A. (1977) [Pubmed]
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