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Gene Review

INHBA  -  inhibin, beta A

Homo sapiens

Synonyms: Activin beta-A chain, EDF, Erythroid differentiation protein, FRP, Inhibin beta A chain
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Disease relevance of INHBA


Psychiatry related information on INHBA

  • These novel observations indicate a coordinate expression and function of an inhibitory Id protein (Id2) and a stimulatory bHLH/bHLH heterodimer (TAL1/E2A) in normal erythroid differentiation [6].

High impact information on INHBA


Chemical compound and disease context of INHBA


Biological context of INHBA


Anatomical context of INHBA


Associations of INHBA with chemical compounds


Physical interactions of INHBA


Enzymatic interactions of INHBA


Regulatory relationships of INHBA


Other interactions of INHBA


Analytical, diagnostic and therapeutic context of INHBA


  1. Specific erythroid differentiation of mouse erythroleukemia cells by activins and its enhancement by retinoic acids. Uchiyama, H., Asashima, M. Biochem. Biophys. Res. Commun. (1992) [Pubmed]
  2. Treatment of vascular retinal disease with pentoxifylline: a controlled, randomized trial. Incandela, L., Cesarone, M.R., Belcaro, G., Steigerwalt, R., De Sanctis, M.T., Nicolaides, A.N., Griffin, M., Geroulakos, G., Ramaswami, G. Angiology. (2002) [Pubmed]
  3. v-erbA oncogene activation entails the loss of hormone-dependent regulator activity of c-erbA. Zenke, M., Muñoz, A., Sap, J., Vennström, B., Beug, H. Cell (1990) [Pubmed]
  4. Protein tyrosine phosphatase PTP1B suppresses p210 bcr-abl-induced transformation of rat-1 fibroblasts and promotes differentiation of K562 cells. LaMontagne, K.R., Hannon, G., Tonks, N.K. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  5. Modulation of retinoblastoma gene in normal adult hematopoiesis: peak expression and functional role in advanced erythroid differentiation. Condorelli, G.L., Testa, U., Valtieri, M., Vitelli, L., De Luca, A., Barberi, T., Montesoro, E., Campisi, S., Giordano, A., Peschle, C. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  6. Coordinate expression and developmental role of Id2 protein and TAL1/E2A heterodimer in erythroid progenitor differentiation. Condorelli, G., Vitelli, L., Valtieri, M., Marta, I., Montesoro, E., Lulli, V., Baer, R., Peschle, C. Blood (1995) [Pubmed]
  7. The beta-globin nuclear compartment in development and erythroid differentiation. Palstra, R.J., Tolhuis, B., Splinter, E., Nijmeijer, R., Grosveld, F., de Laat, W. Nat. Genet. (2003) [Pubmed]
  8. mRNA silencing in erythroid differentiation: hnRNP K and hnRNP E1 regulate 15-lipoxygenase translation from the 3' end. Ostareck, D.H., Ostareck-Lederer, A., Wilm, M., Thiele, B.J., Mann, M., Hentze, M.W. Cell (1997) [Pubmed]
  9. Circulating erythroid progenitors in the anemia of prematurity. Shannon, K.M., Naylor, G.S., Torkildson, J.C., Clemons, G.K., Schaffner, V., Goldman, S.L., Lewis, K., Bryant, P., Phibbs, R. N. Engl. J. Med. (1987) [Pubmed]
  10. Induction by ouabain of hemoglobin synthesis in cultured Friend erythroleukemic cells. Bernstein, A., Hunt, D.M., Crichley, V., Mak, T.W. Cell (1976) [Pubmed]
  11. Induction of erythroid differentiation in vitro by purines and purine analogues. Gusella, J.F., Housman, D. Cell (1976) [Pubmed]
  12. Production of erythropoietin-like activity by a murine erythroleukemia cell line. Tambourin, P., Casadevall, N., Choppin, J., Lacombe, C., Heard, J.M., Fichelson, S., Wendling, F., Varet, B. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  13. Induction of erythroid differentiation of K562 human leukemic cells by herbimycin A, an inhibitor of tyrosine kinase activity. Honma, Y., Okabe-Kado, J., Hozumi, M., Uehara, Y., Mizuno, S. Cancer Res. (1989) [Pubmed]
  14. Changes in DNA associated with induction of erythroid differentiation by dimethyl sulfoxide in murine erythroleukemia cells. Terada, M., Nudel, U., Fibach, E., Rifkind, R.A., Marks, P.A. Cancer Res. (1978) [Pubmed]
  15. Molecular cloning of the porcine inhibin-betaB gene and reassignment to chromosome 15. Nonneman, D., Rohrer, G.A. Anim. Genet. (2003) [Pubmed]
  16. Dinucleotide repeat polymorphism in the INHBA gene. Pang, Z., Pardinas, J.R., Dermody, J., Ozer, H.L. Hum. Mol. Genet. (1993) [Pubmed]
  17. Regulation of human erythropoiesis by activin A, BMP2, and BMP4, members of the TGFbeta family. Maguer-Satta, V., Bartholin, L., Jeanpierre, S., Ffrench, M., Martel, S., Magaud, J.P., Rimokh, R. Exp. Cell Res. (2003) [Pubmed]
  18. p27KIP1 and GATA-1 are potential downstream molecules in activin A-induced differentiation and apoptosis pathways in CML cells. Fukuchi, Y., Yamato, K., Kawamura, C., Ikeda, Y., Kizaki, M. Oncol. Rep. (2006) [Pubmed]
  19. Differentiation of erythroleukemic cells in the presence of inhibitors of DNA synthesis. Leder, A., Orkin, S., Leder, P. Science (1975) [Pubmed]
  20. Induction of differentiation of the human promyelocytic cell line HL-60 by activin/EDF. Yamada, R., Suzuki, T., Hashimoto, M., Eto, Y., Shiokawa, K., Muramatsu, M. Biochem. Biophys. Res. Commun. (1992) [Pubmed]
  21. Presence of activin (erythroid differentiation factor) in unfertilized eggs and blastulae of Xenopus laevis. Asashima, M., Nakano, H., Uchiyama, H., Sugino, H., Nakamura, T., Eto, Y., Ejima, D., Nishimatsu, S., Ueno, N., Kinoshita, K. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  22. The extracts from rat submandibular glands induce the erythroid differentiation of K-562 cells. Sasaki, R., Masuyama, A., Etoh, Y., Yoshida, H., Miura, Y., Sasaki, H. Leuk. Res. (1995) [Pubmed]
  23. Butyric acid, a potent inducer of erythroid differentiation in cultured erythroleukemic cells. Leder, A., Leder, P. Cell (1975) [Pubmed]
  24. Chemical inducers of differentiation in Friend leukaemia cells inhibit lymphocyte mitogenesis. Stenzel, K.H., Schwartz, R., Rubin, A.L., Novogrodsky, A. Nature (1980) [Pubmed]
  25. Accumulation of a heat shock-like protein during differentiation of human erythroid cell line K562. Singh, M.K., Yu, J. Nature (1984) [Pubmed]
  26. Stem cell factor influences the proliferation and erythroid differentiation of the MB-02 human erythroleukemia cell line by binding to a high-affinity c-kit receptor. Broudy, V.C., Morgan, D.A., Lin, N., Zsebo, K.M., Jacobsen, F.W., Papayannopoulou, T. Blood (1993) [Pubmed]
  27. Overexpression of HSF2-beta inhibits hemin-induced heat shock gene expression and erythroid differentiation in K562 cells. Leppä, S., Pirkkala, L., Saarento, H., Sarge, K.D., Sistonen, L. J. Biol. Chem. (1997) [Pubmed]
  28. A fibronectin matrix is required for differentiation of murine erythroleukemia cells into reticulocytes. Patel, V.P., Lodish, H.F. J. Cell Biol. (1987) [Pubmed]
  29. Expression of organic cation transporter OCTN1 in hematopoietic cells during erythroid differentiation. Kobayashi, D., Aizawa, S., Maeda, T., Tsuboi, I., Yabuuchi, H., Nezu, J., Tsuji, A., Tamai, I. Exp. Hematol. (2004) [Pubmed]
  30. Isolation of three proteins that bind to mammalian RNA polymerase II. Sopta, M., Carthew, R.W., Greenblatt, J. J. Biol. Chem. (1985) [Pubmed]
  31. P/CAF-mediated acetylation regulates the function of the basic helix-loop-helix transcription factor TAL1/SCL. Huang, S., Qiu, Y., Shi, Y., Xu, Z., Brandt, S.J. EMBO J. (2000) [Pubmed]
  32. Overexpression of HOXA10 perturbs human lymphomyelopoiesis in vitro and in vivo. Buske, C., Feuring-Buske, M., Antonchuk, J., Rosten, P., Hogge, D.E., Eaves, C.J., Humphries, R.K. Blood (2001) [Pubmed]
  33. SATB1 family protein expressed during early erythroid differentiation modifies globin gene expression. Wen, J., Huang, S., Rogers, H., Dickinson, L.A., Kohwi-Shigematsu, T., Noguchi, C.T. Blood (2005) [Pubmed]
  34. Rescue of early-stage myelodysplastic syndrome-deriving erythroid precursors by the ectopic expression of a dominant-negative form of FADD. Claessens, Y.E., Park, S., Dubart-Kupperschmitt, A., Mariot, V., Garrido, C., Chrétien, S., Dreyfus, F., Lacombe, C., Mayeux, P., Fontenay, M. Blood (2005) [Pubmed]
  35. Erythroblasts are a source of angiogenic factors. Tordjman, R., Delaire, S., Plouët, J., Ting, S., Gaulard, P., Fichelson, S., Roméo, P.H., Lemarchandel, V. Blood (2001) [Pubmed]
  36. Erythroid differentiation factor is encoded by the same mRNA as that of the inhibin beta A chain. Murata, M., Eto, Y., Shibai, H., Sakai, M., Muramatsu, M. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  37. Ectopic expression of a conditional GATA-2/estrogen receptor chimera arrests erythroid differentiation in a hormone-dependent manner. Briegel, K., Lim, K.C., Plank, C., Beug, H., Engel, J.D., Zenke, M. Genes Dev. (1993) [Pubmed]
  38. Constitutive activation of STAT5A promotes human hematopoietic stem cell self-renewal and erythroid differentiation. Schuringa, J.J., Chung, K.Y., Morrone, G., Moore, M.A. J. Exp. Med. (2004) [Pubmed]
  39. The SCL gene product: a positive regulator of erythroid differentiation. Aplan, P.D., Nakahara, K., Orkin, S.H., Kirsch, I.R. EMBO J. (1992) [Pubmed]
  40. Activin A/erythroid differentiation factor is induced during human monocyte activation. Erämaa, M., Hurme, M., Stenman, U.H., Ritvos, O. J. Exp. Med. (1992) [Pubmed]
  41. Mutant N-RAS induces erythroid lineage dysplasia in human CD34+ cells. Darley, R.L., Hoy, T.G., Baines, P., Padua, R.A., Burnett, A.K. J. Exp. Med. (1997) [Pubmed]
  42. Definitive-like erythroid cells derived from human embryonic stem cells coexpress high levels of embryonic and fetal globins with little or no adult globin. Chang, K.H., Nelson, A.M., Cao, H., Wang, L., Nakamoto, B., Ware, C.B., Papayannopoulou, T. Blood (2006) [Pubmed]
  43. Predominant expression of a receptor tyrosine kinase, TIE, in hematopoietic stem cells and B cells. Hashiyama, M., Iwama, A., Ohshiro, K., Kurozumi, K., Yasunaga, K., Shimizu, Y., Masuho, Y., Matsuda, I., Yamaguchi, N., Suda, T. Blood (1996) [Pubmed]
  44. Ribosomal protein S19 expression during erythroid differentiation. Da Costa, L., Narla, G., Willig, T.N., Peters, L.L., Parra, M., Fixler, J., Tchernia, G., Mohandas, N. Blood (2003) [Pubmed]
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