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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The somatostatin analogue SMS 201-995 promotes paradoxical sleep in aged rats.

Sleep patterns were recorded in aged rats (800- to 840-day-old) under control conditions and following either intraperitoneal injections of three different doses of the octapeptide somatostatin analogue SMS 201-995 ( SMS) or after spontaneous oral intake of SMS-containing water (0.003 mg/ml). The intraperitoneal administration of SMS resulted in a dose-dependent and selective increase of paradoxical sleep (SP). Similarly, the spontaneous oral ingestion of SMS induced a significant increase of the daily duration of PS. Slow wave sleep remained unchanged in both cases. These findings confirm previous results demonstrating a role of somatostatin in the generation of PS. In addition, they suggest that sleep deficits during aging may be the consequence of decreased age-related somatostatin release.[1]

References

  1. The somatostatin analogue SMS 201-995 promotes paradoxical sleep in aged rats. Danguir, J. Neurobiol. Aging (1989) [Pubmed]
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