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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Sleep, REM

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Disease relevance of Sleep, REM


Psychiatry related information on Sleep, REM


High impact information on Sleep, REM

  • Here we show that a deficiency in short-chain acyl-coenzyme A dehydrogenase (encoded by Acads) in mice causes a marked slowing in theta frequency during paradoxical sleep only [11].
  • Also, these phases of sleep are differentially sensitive to a number of endogenous neuropeptides and cytokines, including somatostatin, which has been shown to increase REM sleep without significantly affecting other phases [6].
  • It has been hypothesized that REM (rapid eye movement) sleep has an important role in memory consolidation [12].
  • Microinjection of this pharmacologically active probe into the gigantocellular field of the cat pontine brain stem caused the awake cats to fall into rapid movement (REM) sleep indistinguishable from that produced by free carbachol [13].
  • Arecoline, a cholinergic muscarinic receptor agonist, induced rapid eye movement sleep significantly more rapidly in patients with primary affective illness in remission than in normal control subjects matched for age and sex [14].

Chemical compound and disease context of Sleep, REM

  • Newborn infants, chronically exposed in utero to low doses of methadone with or without concomitant heroin, display more rapid eye movement sleep and less quiet sleep than control infants, while babies fetally exposed to both opiates and nonopiates have less organization of sleep states [15].
  • A trend for an association between lower amounts of REM sleep and higher evening cortisol concentrations independent of age was detected (P<.10) [16].
  • In five goats provided with chronic sagittal sinus fistulae, arteriovenous oxygen difference was measured in separate studies and found to be significantly lower during REM sleep compared with W; brain O2 consumption was similar in magnitude in the REM and W states [17].
  • The dopamine agonist significantly decreased rapid eye movement (REM) sleep and percent REM sleep and increased REM latency [18].
  • Physostigmine, an anticholinesterase that increases the action of brain acetylcholine, induces rapid eye movement (REM) sleep in normal humans [19].
  • In the discussion, arguments supporting the requirement for a given level of noradrenaline for REM sleep occurrence are presented [20].

Biological context of Sleep, REM


Anatomical context of Sleep, REM


Gene context of Sleep, REM


Analytical, diagnostic and therapeutic context of Sleep, REM


  1. Acetylcholine in mind: a neurotransmitter correlate of consciousness? Perry, E., Walker, M., Grace, J., Perry, R. Trends Neurosci. (1999) [Pubmed]
  2. The effect of oxygen on respiration and sleep in patients with congestive heart failure. Hanly, P.J., Millar, T.W., Steljes, D.G., Baert, R., Frais, M.A., Kryger, M.H. Ann. Intern. Med. (1989) [Pubmed]
  3. 24-hour profiles of adrenocorticotropin, cortisol, and growth hormone in major depressive illness: effect of antidepressant treatment. Linkowski, P., Mendlewicz, J., Kerkhofs, M., Leclercq, R., Golstein, J., Brasseur, M., Copinschi, G., Van Cauter, E. J. Clin. Endocrinol. Metab. (1987) [Pubmed]
  4. Rapid eye movement sleep alterations in myasthenia gravis. Papazian, O. Neurology (1976) [Pubmed]
  5. Enhanced slow wave sleep in patients with prolactinoma. Frieboes, R.M., Murck, H., Stalla, G.K., Antonijevic, I.A., Steiger, A. J. Clin. Endocrinol. Metab. (1998) [Pubmed]
  6. A cortical neuropeptide with neuronal depressant and sleep-modulating properties. de Lecea, L., Criado, J.R., Prospero-Garcia, O., Gautvik, K.M., Schweitzer, P., Danielson, P.E., Dunlop, C.L., Siggins, G.R., Henriksen, S.J., Sutcliffe, J.G. Nature (1996) [Pubmed]
  7. To eat or to sleep? Orexin in the regulation of feeding and wakefulness. Willie, J.T., Chemelli, R.M., Sinton, C.M., Yanagisawa, M. Annu. Rev. Neurosci. (2001) [Pubmed]
  8. Flurazepam hydrochloride, a benzodiazepine hypnotic. Greenblatt, D.J., Shader, R.I., Koch-Weser, J. Ann. Intern. Med. (1975) [Pubmed]
  9. Prostaglandin E2 and its methyl ester reduce cataplexy in canine narcolepsy. Nishino, S., Mignot, E., Fruhstorfer, B., Dement, W.C., Hayaishi, O. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  10. Effects of thyrotropin-releasing hormone and its analogs on daytime sleepiness and cataplexy in canine narcolepsy. Nishino, S., Arrigoni, J., Shelton, J., Kanbayashi, T., Dement, W.C., Mignot, E. J. Neurosci. (1997) [Pubmed]
  11. Deficiency in short-chain fatty acid beta-oxidation affects theta oscillations during sleep. Tafti, M., Petit, B., Chollet, D., Neidhart, E., de Bilbao, F., Kiss, J.Z., Wood, P.A., Franken, P. Nat. Genet. (2003) [Pubmed]
  12. The REM sleep-memory consolidation hypothesis. Siegel, J.M. Science (2001) [Pubmed]
  13. Mapping neuronal inputs to REM sleep induction sites with carbachol-fluorescent microspheres. Quattrochi, J.J., Mamelak, A.N., Madison, R.D., Macklis, J.D., Hobson, J.A. Science (1989) [Pubmed]
  14. Faster cholinergic REM sleep induction in euthymic patients with primary affective illness. Sitaram, N., Nurnberger, J.I., Gershon, E.S., Gillin, J.C. Science (1980) [Pubmed]
  15. Fetal exposure to narcotics: neonatal sleep as a measure of nervous system disturbance. Dinges, D.F., Davis, M.M., Glass, P. Science (1980) [Pubmed]
  16. Age-related changes in slow wave sleep and REM sleep and relationship with growth hormone and cortisol levels in healthy men. Van Cauter, E., Leproult, R., Plat, L. JAMA (2000) [Pubmed]
  17. Correlation between ventilation and brain blood flow during sleep. Santiago, T.V., Guerra, E., Neubauer, J.A., Edelman, N.H. J. Clin. Invest. (1984) [Pubmed]
  18. Effects of a dopamine agonist piribedil in depressed patients: relationship of pretreatment homovanillic acid to antidepressant response. Post, R.M., Gerner, R.H., Carman, J.S., Gillin, J.C., Jimerson, D.C., Goodwin, F.K., Bunney, W.E. Arch. Gen. Psychiatry (1978) [Pubmed]
  19. The effect of physostigmine on normal human sleep and dreaming. Sitaram, N., Moore, A.M., Gillin, J.C. Arch. Gen. Psychiatry (1978) [Pubmed]
  20. Noradrenaline involvement in basic and higher integrated REM sleep processes. Gottesmann, C. Prog. Neurobiol. (2008) [Pubmed]
  21. Human sleep: its duration and organization depend on its circadian phase. Czeisler, C.A., Weitzman, E., Moore-Ede, M.C., Zimmerman, J.C., Knauer, R.S. Science (1980) [Pubmed]
  22. Diurnal rhythm of plasma delta-sleep-inducing peptide in humans: evidence for positive correlation with body temperature and negative correlation with rapid eye movement and slow wave sleep. Friedman, T.C., Garcia-Borreguero, D., Hardwick, D., Akuete, C.N., Stambuk, M.K., Dorn, L.D., Starkman, M.N., Loh, Y.P., Chrousos, G.P. J. Clin. Endocrinol. Metab. (1994) [Pubmed]
  23. Neuroendocrine processes underlying ultradian sleep regulation in man. Gronfier, C., Simon, C., Piquard, F., Ehrhart, J., Brandenberger, G. J. Clin. Endocrinol. Metab. (1999) [Pubmed]
  24. Morphinelike arousal by methadone during sleep. Pickworth, W.B., Neidert, G.L., Kay, D.C. Clin. Pharmacol. Ther. (1981) [Pubmed]
  25. Role of hypoxia on increased blood pressure in patients with obstructive sleep apnoea. Okabe, S., Hida, W., Kikuchi, Y., Taguchi, O., Ogawa, H., Mizusawa, A., Miki, H., Shirato, K. Thorax (1995) [Pubmed]
  26. Carbachol stimulates [35S]guanylyl 5'-(gamma-thio)-triphosphate binding in rapid eye movement sleep-related brainstem nuclei of rat. Capece, M.L., Baghdoyan, H.A., Lydic, R. J. Neurosci. (1998) [Pubmed]
  27. Microdialysis perfusion of 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) in the dorsal raphe nucleus decreases serotonin release and increases rapid eye movement sleep in the freely moving cat. Portas, C.M., Thakkar, M., Rainnie, D., McCarley, R.W. J. Neurosci. (1996) [Pubmed]
  28. Simultaneous pontine and basal forebrain microinjections of carbachol suppress REM sleep. Baghdoyan, H.A., Spotts, J.L., Snyder, S.G. J. Neurosci. (1993) [Pubmed]
  29. Behavioral habituation to spatial novelty: interference and noninterference studies. Cerbone, A., Sadile, A.G. Neuroscience and biobehavioral reviews. (1994) [Pubmed]
  30. Sleep-related brain activation does not increase the permeability of the blood-brain barrier to glucose. Silvani, A., Asti, V., Berteotti, C., Bojic, T., Cianci, T., Ferrari, V., Franzini, C., Lenzi, P., Zoccoli, G. J. Cereb. Blood Flow Metab. (2005) [Pubmed]
  31. Distinct narcolepsy syndromes in Orexin receptor-2 and Orexin null mice: molecular genetic dissection of Non-REM and REM sleep regulatory processes. Willie, J.T., Chemelli, R.M., Sinton, C.M., Tokita, S., Williams, S.C., Kisanuki, Y.Y., Marcus, J.N., Lee, C., Elmquist, J.K., Kohlmeier, K.A., Leonard, C.S., Richardson, J.A., Hammer, R.E., Yanagisawa, M. Neuron (2003) [Pubmed]
  32. Behavioral correlates of activity in identified hypocretin/orexin neurons. Mileykovskiy, B.Y., Kiyashchenko, L.I., Siegel, J.M. Neuron (2005) [Pubmed]
  33. Key role of 5-HT1B receptors in the regulation of paradoxical sleep as evidenced in 5-HT1B knock-out mice. Boutrel, B., Franc, B., Hen, R., Hamon, M., Adrien, J. J. Neurosci. (1999) [Pubmed]
  34. Somatostatin impairs sleep in elderly human subjects. Frieboes, R.M., Murck, H., Schier, T., Holsboer, F., Steiger, A. Neuropsychopharmacology (1997) [Pubmed]
  35. Changes in hypothalamic corticotropin-releasing hormone, neuropeptide Y, and proopiomelanocortin gene expression during chronic rapid eye movement sleep deprivation of rats. Koban, M., Le, W.W., Hoffman, G.E. Endocrinology (2006) [Pubmed]
  36. Sleep and sleep electroencephalogram in depressed patients treated with phenelzine. Landolt, H.P., Raimo, E.B., Schnierow, B.J., Kelsoe, J.R., Rapaport, M.H., Gillin, J.C. Arch. Gen. Psychiatry (2001) [Pubmed]
  37. Increased activation of anterior paralimbic and executive cortex from waking to rapid eye movement sleep in depression. Nofzinger, E.A., Buysse, D.J., Germain, A., Carter, C., Luna, B., Price, J.C., Meltzer, C.C., Miewald, J.M., Reynolds, C.F., Kupfer, D.J. Arch. Gen. Psychiatry (2004) [Pubmed]
  38. Rapid eye movement sleep correlates with the overall activities of the hypothalamic-pituitary-adrenal axis and sympathetic system in healthy humans. Vgontzas, A.N., Bixler, E.O., Papanicolaou, D.A., Kales, A., Stratakis, C.A., Vela-Bueno, A., Gold, P.W., Chrousos, G.P. J. Clin. Endocrinol. Metab. (1997) [Pubmed]
  39. Melatonin in patients with reduced REM sleep duration: two randomized controlled trials. Kunz, D., Mahlberg, R., Müller, C., Tilmann, A., Bes, F. J. Clin. Endocrinol. Metab. (2004) [Pubmed]
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