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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Platelet volume, density and 5 HT organelles (mepacrine test) in acute leukaemia.

Qualitative platelet parameters (volume, 5 hydroxy-tryptamine (5 HT) organelles studied by the mepacrine test, and density) were evaluated in 31 patients with acute leukaemia: 11 myelomonocytic (AML), 8 lymphoblastic (ALL), 12 granulocytic ( AGL). Macrothrombocytosis was observed in most of the cases of AML, was rare in AGL and was never found in ALL. The 5 HT organelles/volume ratio was normal in AGL and ALL but was significantly decreased in AML. In contrast, platelet density distribution was always abnormal whatever the platelet volume and 5 HT organelle concentration. Thus, using simple new methods, convenient even in cases of thrombocytopenia, we demonstrate that qualitative platelet abnormalities are a constant feature in acue leukaemia and that they are more severe in AML.[1]


  1. Platelet volume, density and 5 HT organelles (mepacrine test) in acute leukaemia. Nouvel, C., Caranobe, C., Sie, P., Capdeville, J., Pris, J., Boneu, B. Scandinavian journal of haematology. (1978) [Pubmed]
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