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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Simple fluorimetric screening for carazolol in swine kidneys by means of Sep-Pak cartridges.

A simple method to determine the beta-blocker carazolol in swine kidneys is presented. Spiked samples, homogenised under alkaline conditions, were heated. Passage of the ether extracts through C18 and silica Sep-Pak cartridges yielded a fraction containing the carazolol in 88% recovery. In this fraction carazolol was determined by fluorescence spectrophotometry. By this method a level of 1 microgram/kg in spiked samples can be detected. Injection of 10 micrograms/kg body weight, 105 minutes before slaughter, resulted in carazolol contents in kidneys ranging from 11 to 25 micrograms/kg (n = 8).[1]

References

  1. Simple fluorimetric screening for carazolol in swine kidneys by means of Sep-Pak cartridges. Engelsma, J.W., Simons, J. The Veterinary quarterly. (1985) [Pubmed]
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