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Brizer, D.A. et al.

Effect of methadone plus neuroleptics on treatment-resistant chronic paranoid schizophrenia.

In a placebo-controlled single-crossover study, seven patients with treatment-resistant chronic paranoid schizophrenia who received methadone plus neuroleptic showed significant improvement. Methadone may be a useful adjunctive treatment in a subpopulation of patients with chronic paranoid schizophrenia.[1]

References

Effect of methadone plus neuroleptics on treatment-resistant chronic paranoid schizophrenia. Brizer, D.A., Hartman, N., Sweeney, J., Millman, R.B. The American journal of psychiatry. (1985) [Pubmed]

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