Chemical Compound Review:
Amidone 6-dimethylamino-4,4-diphenyl- heptan-3-one
Synonyms:
Biscuits, Diaminon, Dolophin, Dolophine, Metasedin, ...
Chawarski,
Lilly,
LaForge,
Sheffels,
Fiellin,
Pollack,
Daniel D. Langleben,
Kosha Ruparel,
Igor Elman,
Samantha Busch-Winokur,
Ramapriyan Pratiwadi,
James Loughead,
Charles P. O'Brien,
Anna R. Childress,
Kreek,
Bart,
O'Connor,
Pantalon,
D'Aunno,
Nielsen,
Pakes,
Kharasch,
Hoffer,
Schottenfeld,
Francesco Leri,
Jane Stewart,
James G. Pfaus,
Whittington,
Erin Cummins,
Robert E. Sorge,
David Woehrling,
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- Letter: Methadone-associated gynecomastia. Thomas, B.L. N. Engl. J. Med. (1976)
- Markers for detection of supplementation in narcotic programs--deuterium-labeled methadone. Hsia, J.C., Tam, J.C., Giles, H.G., Leung, C.C., Marcus, H., Marshman, J.A., Leblanc, A.E. Science (1976)
- Dyskinesias elicited by methamphetamine: susceptibility of former methadone-consuming monkeys. Eibergen, R.D., Carlson, K.R. Science (1975)
- Hepatitis B surface antigen and antibody. A prospective study in asymptomatic drug abusers. Stimmel, B., Vernace, S., Schaffner, F. JAMA (1975)
- A stepped care strategy using buprenorphine and methadone versus conventional methadone maintenance in heroin dependence: a randomized controlled trial. Kakko, J., Grönbladh, L., Svanborg, K.D., von Wachenfeldt, J., Rück, C., Rawlings, B., Nilsson, L.H., Heilig, M. Am. J. Psychiatry (2007)
- Acute effect of methadone maintenance dose on brain FMRI response to heroin-related cues. Langleben, D.D., Ruparel, K., Elman, I., Busch-Winokur, S., Pratiwadi, R., Loughead, J., O'Brien, C.P., Childress, A.R. Am. J. Psychiatry (2008)
- Pharmacogenetics and human molecular genetics of opiate and cocaine addictions and their treatments. Kreek, M.J., Bart, G., Lilly, C., LaForge, K.S., Nielsen, D.A. Pharmacol. Rev. (2005)
- Fetal exposure to narcotics: neonatal sleep as a measure of nervous system disturbance. Dinges, D.F., Davis, M.M., Glass, P. Science (1980)
- Changes in methadone treatment practices: results from a national panel study, 1988-2000. D'Aunno, T., Pollack, H.A. JAMA (2002)
- Prevalence and characteristics of chronic pain among chemically dependent patients in methadone maintenance and residential treatment facilities. Rosenblum, A., Joseph, H., Fong, C., Kipnis, S., Cleland, C., Portenoy, R.K. JAMA (2003)
- Narcotic dependency in pregnancy. Methadone maintenance compared to use of street drugs. Stimmel, B., Adamsons, K. JAMA (1976)
- Function of the male sex organs in heroin and methadone users. Cicero, T.J., Bell, R.D., Wiest, W.G., Allison, J.H., Polakoski, K., Robins, E. N. Engl. J. Med. (1975)
- Microsomal enzyme induction by methadone and its implications on tolerance to methodone lethality. Masten, L.W., Peterson, G.R., Burkhalter, A., Way, E.L. Nature (1975)
- Methadone conformation and opioid activity. Duax, W.L., Smith, G.D., Griffin, J.F., Portoghese, P.S. Science (1983)
- Cocaine use and HIV infection in intravenous drug users in San Francisco. Chaisson, R.E., Bacchetti, P., Osmond, D., Brodie, B., Sande, M.A., Moss, A.R. JAMA (1989)
- Methadone, ciprofloxacin, and adverse drug reactions. Herrlin, K., Segerdahl, M., Gustafsson, L.L., Kalso, E. Lancet (2000)
- Changes in attitude toward methadone. Brown, B.S., Jansen, D.R., Benn, G.J. Arch. Gen. Psychiatry (1975)
- Clonidine in outpatient detoxification from methadone maintenance. Kleber, H.D., Riordan, C.E., Rounsaville, B., Kosten, T., Charney, D., Gaspari, J., Hogan, I., O'Connor, C. Arch. Gen. Psychiatry (1985)
- Use of disulfiram for alcoholics in methadone maintenance programs. A Veterans Administration Cooperative Study. Ling, W., Weiss, D.G., Charuvastra, V.C., O'Brien, C.P. Arch. Gen. Psychiatry (1983)
- HIV screening and counseling for intravenous drug abuse patients. Staff and patient attitudes. Curtis, J.L., Crummey, F.C., Baker, S.N., Foster, R.E., Khanyile, C.S., Wilkins, R. JAMA (1989)
- Hepatic extraction of long- and short-acting narcotics in the isolated perfused rabbit liver. Kreek, M.J., Oratz, M., Rothschild, M.A. Gastroenterology (1978)
- The stimulation of albumin sythesis by methadone. Rothschild, M.A., Kreek, M.J., Oratz, M., Schreiber, S.S., Mongelli, J.G. Gastroenterology (1976)
- Controlling the abuse of illicit methadone in Washington, DC. Greene, M.H., Brown, B.S., DuPont, R.L. Arch. Gen. Psychiatry (1975)
- Physiological and psychological effects of methadone in man. Gritz, E.R., Shiffman, S.M., Jarvik, M.E., Haber, J., Dymond, A.M., Coger, R., Charuvastra, V., Schlesinger, J. Arch. Gen. Psychiatry (1975)
- Effects of opiates and demographic factors on DNA repair synthesis in human leukocytes. Madden, J.J., Falek, A., Shafer, D.A., Glick, J.H. Proc. Natl. Acad. Sci. U.S.A. (1979)
- Acute effects of ethanol on hepatic uptake and distribution of narcotics in the isolated perfused rabbit liver. Kreek, M.J., Rothschild, M.A., Oratz, M., Mongelli, J., Handley, A.C. Hepatology (1981)
- Immune function and anti-HTLV-I/II status in anti-HIV-1-negative intravenous drug users receiving methadone. Klimas, N.G., Blaney, N.T., Morgan, R.O., Chitwood, D., Milles, K., Lee, H., Fletcher, M.A. Am. J. Med. (1991)
- Methadyl acetate and methadone. An open comparison. Senay, E.C., Dorus, W., Renault, P.F. JAMA (1977)
- Methadone blockade of 2-deoxyglucose-induced pancreatic secretion in the rat. Rozé, C., Chariot, J., de La Tour, J., Souchard, M., Vaille, C., Debray, C. Gastroenterology (1978)
- Pharmacotherapy for cocaine-abusing methadone-maintained patients using amantadine or desipramine. Kosten, T.R., Morgan, C.M., Falcione, J., Schottenfeld, R.S. Arch. Gen. Psychiatry (1992)
- Imipramine as treatment for depression in addicts. Kleber, H.D., Weissman, M.M., Rounsaville, B.J., Wilber, C.H., Prusoff, B.A., Riordan, C.E. Arch. Gen. Psychiatry (1983)
- High-dose methadone maintenance in rats: effects on cocaine self-administration and behavioral side effects. Leri, F., Sorge, R.E., Cummins, E., Woehrling, D., Pfaus, J.G., Stewart, J. Neuropsychopharmacology (2007)
- Role of hepatic and intestinal cytochrome P450 3A and 2B6 in the metabolism, disposition, and miotic effects of methadone. Kharasch, E.D., Hoffer, C., Whittington, D., Sheffels, P. Clin. Pharmacol. Ther. (2004)
- ABCB1 and cytochrome P450 genotypes and phenotypes: influence on methadone plasma levels and response to treatment. Crettol, S., Déglon, J.J., Besson, J., Croquette-Krokar, M., Hämmig, R., Gothuey, I., Monnat, M., Eap, C.B. Clin. Pharmacol. Ther. (2006)
- Methadone enantiomer plasma levels, CYP2B6, CYP2C19, and CYP2C9 genotypes, and response to treatment. Crettol, S., Déglon, J.J., Besson, J., Croquette-Krokkar, M., Gothuey, I., Hämmig, R., Monnat, M., Hüttemann, H., Baumann, P., Eap, C.B. Clin. Pharmacol. Ther. (2005)
- In Vivo Activation of Human Pregnane X Receptor Tightens the Blood-Brain Barrier to Methadone through P-Glycoprotein Up-Regulation. Bauer, B., Yang, X., Hartz, A.M., Olson, E.R., Zhao, R., Kalvass, J.C., Pollack, G.M., Miller, D.S. Mol. Pharmacol. (2006)
- Opiate withdrawal in utero increases neonatal morbidity in the rat. Lichtblau, L., Sparber, S.B. Science (1981)
- Methadone maintenance in primary care: a randomized controlled trial. Fiellin, D.A., O'Connor, P.G., Chawarski, M., Pakes, J.P., Pantalon, M.V., Schottenfeld, R.S. JAMA (2001)
- Moderate- vs high-dose methadone in the treatment of opioid dependence: a randomized trial. Strain, E.C., Bigelow, G.E., Liebson, I.A., Stitzer, M.L. JAMA (1999)
- Drug addiction in pregnancy. Fraser, A.C. Lancet (1976)