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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Effect of carbon dioxide in acute mountain sickness: a rediscovery.

The effect of adding CO2 to inhaled air in six subjects with acute mountain sickness was investigated during a medical expedition to 5400 m.3% CO2 in ambient air increased ventilation and resulted in a rise in PaO2 of between 24% and 40%. There was a 9-28% increase in PaCO2 and a reduction of the respiratory alkalosis normally seen at high altitude. Symptoms of acute mountain sickness were rapidly relieved. In three subjects cerebral blood flow increased by 17-39%, so that oxygen delivery to the brain would have been considerably improved. This study confirms earlier suggestions of the beneficial effect of CO2 inhalation at high altitude.[1]


  1. Effect of carbon dioxide in acute mountain sickness: a rediscovery. Harvey, T.C., Raichle, M.E., Winterborn, M.H., Jensen, J., Lassen, N.A., Richardson, N.V., Bradwell, A.R. Lancet (1988) [Pubmed]
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