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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

The role of aldosterone in water and electrolyte transport across the colonic epithelium of the lizard, Gallotia galloti.

1. The effects of D-aldosterone on the electrical properties and ionic transport have been analysed (in vitro) in the colonic epithelium of the lizard, Gallotia galloti. 2. The injection of 30 g of D-aldosterone induced a significant rise of plasma aldosterone concentration, sustained for 4 hr after administration. 3. Intraperitoneal injections of D-aldosterone caused a slight reduction of transmural potential difference (PD) and short-circuit current (Isc). 4. Net absorption of Na+ across the colon from aldosterone-treated lizards did not increase when compared to colon from normal lizards. Cl- absorption was increased in treated lizards. 5. Addition of mucosal barium to treated tissues brought about a sustained increase of PD and Isc. 6. The absorption of fluid in normal lizards was reversed to fluid secretion in treated lizards. 7. The effects of D-aldosterone on lizard colon are compared with those reported for the colon of mammals and birds.[1]

References

  1. The role of aldosterone in water and electrolyte transport across the colonic epithelium of the lizard, Gallotia galloti. Diaz, M., Lorenzo, A., Badia, P., Gomez, T. Comparative biochemistry and physiology. A, Comparative physiology. (1988) [Pubmed]
 
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