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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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An antitermination protein engages the elongating transcription apparatus at a promoter-proximal recognition site.

As a transcriptional activator, the N protein of phage lambda acts to suppress transcription termination by recognizing a promoter-proximal site, nut, which is separated from the terminators by thousands of base pairs. We demonstrate here that N interacts with the elongating RNA polymerase in transit through the boxB domain of nut. This interaction leads to the stable association of N as an integral component of the transcription apparatus. During subsequent elongation, N translocates along with polymerase through several defined terminators positioned beyond nut. Therefore, by being an operon-specific subunit of the transcription apparatus, N presumably prevents the interaction of polymerase with termination signals.[1]

References

  1. An antitermination protein engages the elongating transcription apparatus at a promoter-proximal recognition site. Barik, S., Ghosh, B., Whalen, W., Lazinski, D., Das, A. Cell (1987) [Pubmed]
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