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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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c-fos expression is neither sufficient nor obligatory for differentiation of monomyelocytes to macrophages.

The c-fos gene is rapidly and transiently expressed when human U-937 and HL-60 leukemia cells are induced to differentiate to macrophages. We show that the expression of c-fos is controlled primarily at the transcriptional level. c-fos mRNA is very labile, with a half-life of less than 30 min. Superinduction of c-fos in the presence of cycloheximide occurs primarily because of stabilization of c-fos mRNA. When U-937 cells are serum-stimulated or treated with diacylglycerol, a c-kinase agonist, c-fos is transiently expressed to high levels; however, the cells fail to differentiate to macrophages. Furthermore, HL-60 cell variants resistant to TPA can be induced to differentiate to macrophages in the absence of detectable c-fos expression.[1]

References

  1. c-fos expression is neither sufficient nor obligatory for differentiation of monomyelocytes to macrophages. Mitchell, R.L., Henning-Chubb, C., Huberman, E., Verma, I.M. Cell (1986) [Pubmed]
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