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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Interactions of the anti-tumor ametantrone and mitoxantrone with rat hepatic microsomes.

The interaction of the anti-tumor anthraquinones, ametantrone and mitoxantrone, with rat hepatic microsomes has been studied with a fluorescence technique using 7,12-dimethylbenzanthracene as a new fluorescent probe. The two drugs were able to quench the intrinsic fluorescence of microsomal suspension. Mitoxantrone was able to displace dimethylbenzanthracene bound microsomes with a linear representation of one ligand-one acceptor model, whereas bimodal shape was found in the case of ametantrone. The mechanism of quenching and/or binding is discussed.[1]

References

  1. Interactions of the anti-tumor ametantrone and mitoxantrone with rat hepatic microsomes. al-Gailany, K.A., Alwan, A.H. Biochem. Pharmacol. (1988) [Pubmed]
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