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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Virally induced modulation of murine IgG antibody subclasses.

The isotypic distribution of murine IgG was examined after infection with several viruses. The results indicate that when a hypergammaglobulinemia was induced by the infection, it was restricted to the IgG2a and, to a lesser extent, to the IgG2b subclasses. In addition, when mice were infected with some viruses concomitantly with the immunization with a soluble protein antigen, a modification in the isotypic distribution of antiprotein antibodies was observed, with a preferential production of IgG2a. These observations indicate that viral infections can actively influence the switch of Igs and selectively stimulate the production of the IgG2a subclass.[1]


  1. Virally induced modulation of murine IgG antibody subclasses. Coutelier, J.P., van der Logt, J.T., Heessen, F.W., Vink, A., van Snick, J. J. Exp. Med. (1988) [Pubmed]
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