Gene Review:
Ighg2b - immunoglobulin heavy constant gamma 2B
Mus musculus
Synonyms:
Ig gamma-2B chain C region, IgG2b, Igh-3, gamma2b
- Further evidence that BALB/c and C57BL/6 gamma 2a genes originate from two distinct isotypes. Morgado, M.G., Cam, P., Gris-Liebe, C., Cazenave, P.A., Jouvin-Marche, E. EMBO J. (1989)
- mRNA for surface immunoglobulin gamma chains encodes a highly conserved transmembrane sequence and a 28-residue intracellular domain. Tyler, B.M., Cowman, A.F., Gerondakis, S.D., Adams, J.M., Bernard, O. Proc. Natl. Acad. Sci. U.S.A. (1982)
- Isolation and characterization of anti-monosialoganglioside monoclonal antibody 19-9 class-switch variants. Steplewski, Z., Spira, G., Blaszczyk, M., Lubeck, M.D., Radbruch, A., Illges, H., Herlyn, D., Rajewsky, K., Scharff, M. Proc. Natl. Acad. Sci. U.S.A. (1985)
- Sequences near the 3' secretion-specific polyadenylation site influence levels of secretion-specific and membrane-specific IgG2b mRNA in myeloma cells. Kobrin, B.J., Milcarek, C., Morrison, S.L. Mol. Cell. Biol. (1986)
- Loss of a consensus splice signal in a mutant immunoglobulin gene eliminates the CH1 domain exon from the mRNA. Brandt, C.R., Morrison, S.L., Birshtein, B.K., Milcarek, C. Mol. Cell. Biol. (1984)
- Structure and binding properties of a monoclonal anti-idiotypic autoantibody to anti-DNA with epibody activity. Fischel, R., Eilat, D. J. Immunol. (1992)
- Isotype switching in murine pre-B cell lines. Akira, S., Sugiyama, H., Yoshida, N., Kikutani, H., Yamamura, Y., Kishimoto, T. Cell (1983)
- Gene conversion and polymorphism: generation of mouse immunoglobulin gamma 2a chain alleles by differential gene conversion by gamma 2b chain gene. Ollo, R., Rougeon, F. Cell (1983)
- Repetitive sequences in class-switch recombination regions of immunoglobulin heavy chain genes. Kataoka, T., Miyata, T., Honjo, T. Cell (1981)
- Immunogenicity of Streptococcus pneumoniae type 14 capsular polysaccharide: influence of carriers and adjuvants on isotype distribution. van de Wijgert, J.H., Verheul, A.F., Snippe, H., Check, I.J., Hunter, R.L. Infect. Immun. (1991)
- Production and characterization of monoclonal antibodies to the EDTA extract of Leptospira interrogans, serovar icterohaemorrhagiae. Leite, L.T., Resende, M., de Souza, W., Camargos, E.R., Koury, M.C. Rev. Soc. Bras. Med. Trop. (1996)
- Identification of soluble Fc receptors in mouse serum and the conditioned medium of stimulated B cells. Pure, E., Durie, C.J., Summerill, C.K., Unkeless, J.C. J. Exp. Med. (1984)
- Protection of trinitrobenzene sulfonic acid-induced colitis by an interleukin 2-IgG2b fusion protein in mice. Stallmach, A., Wittig, B., Giese, T., Pfister, K., Hoffmann, J.C., Bulfone-Paus, S., Kunzendorf, U., Meuer, S.C., Zeitz, M. Gastroenterology (1999)
- Antitumor effect of adriamycin entrapped in liposomes conjugated with anti-human alpha-fetoprotein monoclonal antibody. Konno, H., Suzuki, H., Tadakuma, T., Kumai, K., Yasuda, T., Kubota, T., Ohta, S., Nagaike, K., Hosokawa, S., Ishibiki, K. Cancer Res. (1987)
- Gene segments encoding transmembrane carboxyl termini of immunoglobulin gamma chains. Rogers, J., Choi, E., Souza, L., Carter, C., Word, C., Kuehl, M., Eisenberg, D., Wall, R. Cell (1981)
- Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genes. Sakano, H., Maki, R., Kurosawa, Y., Roeder, W., Tonegawa, S. Nature (1980)
- Transforming growth factor beta 1 selectivity stimulates immunoglobulin G2b secretion by lipopolysaccharide-activated murine B cells. McIntyre, T.M., Klinman, D.R., Rothman, P., Lugo, M., Dasch, J.R., Mond, J.J., Snapper, C.M. J. Exp. Med. (1993)
- Chromosomal location of the structural gene cluster encoding murine immunoglobulin heavy chains. D'Eustachio, P., Pravtcheva, D., Marcu, K., Ruddle, F.H. J. Exp. Med. (1980)
- IgG subclass, IgE, and IgA anti-trinitrophenyl antibody production within trinitrophenyl-Ficoll-responsive B cell clones. Evidence in support of three distinct switching pathways. Mongini, P.K., Paul, W.E., Metcalf, E.S. J. Exp. Med. (1983)
- Complement activation selectively potentiates the pathogenicity of the IgG2b and IgG3 isotypes of a high affinity anti-erythrocyte autoantibody. Azeredo da Silveira, S., Kikuchi, S., Fossati-Jimack, L., Moll, T., Saito, T., Verbeek, J.S., Botto, M., Walport, M.J., Carroll, M., Izui, S. J. Exp. Med. (2002)
- T cell regulation of immunoglobulin class expression in the antibody response to trinitrophenyl-ficoll. Evidence for T cell enhancement of the immunoglobulin class switch. Mongini, P.K., Paul, W.E., Metcalf, E.S. J. Exp. Med. (1982)
- The polypeptide of immunoglobulin G influences its galactosylation in vivo. Lee, S.O., Connolly, J.M., Ramirez-Soto, D., Poretz, R.D. J. Biol. Chem. (1990)
- Site of binding of IgG2b and IgG2a by mouse macrophage Fc receptors by using cyanogen bromide fragments. Diamond, B., Boccumini, L., Birshtein, B.K. J. Immunol. (1985)
- Antibody isotype-specific engagement of Fcgamma receptors regulates B lymphocyte depletion during CD20 immunotherapy. Hamaguchi, Y., Xiu, Y., Komura, K., Nimmerjahn, F., Tedder, T.F. J. Exp. Med. (2006)
- Lysine 322 in the human IgG3 C(H)2 domain is crucial for antibody dependent complement activation. Thommesen, J.E., Michaelsen, T.E., Løset GA, n.u.l.l., Sandlie, I., Brekke, O.H. Mol. Immunol. (2000)
- Isotype distribution and specificity of the antibody response to primary Moloney murine sarcoma virus infection in BALB/c mice. Powell, T.J., Gaupp, B., Epps, J.M., Srinivas, R.V., Lamon, E.W. Viral Immunol. (1989)
- The murine macrophage Fc receptor for IgG2b is lipid dependent. Anderson, C.L. J. Immunol. (1980)
- Induction of arthritis by single monoclonal IgG anti-collagen type II antibodies and enhancement of arthritis in mice lacking inhibitory FcgammaRIIB. Nandakumar, K.S., Andrén, M., Martinsson, P., Bajtner, E., Hellström, S., Holmdahl, R., Kleinau, S. Eur. J. Immunol. (2003)
- The C(H)1 and transmembrane domains of mu in the context of a gamma2b transgene do not suffice to promote B cell maturation. Shen, X., Bozek, G., Pinkert, C.A., Storb, U. Int. Immunol. (1999)
- Effect of anti-interleukin 12 treatment on murine lyme borreliosis. Anguita, J., Persing, D.H., Rincon, M., Barthold, S.W., Fikrig, E. J. Clin. Invest. (1996)
- Meningococcal lipopolysaccharide (LPS)-derived oligosaccharide-protein conjugates evoke outer membrane protein- but not LPS-specific bactericidal antibodies in mice: influence of adjuvants. Verheul, A.F., Van Gaans, J.A., Wiertz, E.J., Snippe, H., Verhoef, J., Poolman, J.T. Infect. Immun. (1993)
- FcgammaRIV: a novel FcR with distinct IgG subclass specificity. Nimmerjahn, F., Bruhns, P., Horiuchi, K., Ravetch, J.V. Immunity (2005)
- Defective Fc gamma RII gene expression in macrophages of NOD mice: genetic linkage with up-regulation of IgG1 and IgG2b in serum. Luan, J.J., Monteiro, R.C., Sautès, C., Fluteau, G., Eloy, L., Fridman, W.H., Bach, J.F., Garchon, H.J. J. Immunol. (1996)
- Immunoglobulin VH region genes of the mouse are organized in overlapping clusters. Blankenstein, T., Krawinkel, U. Eur. J. Immunol. (1987)
- Cloning immunoglobulin gamma 2b chain gene of mouse: characterization and partial sequence determination. Kataoka, T., Yamawaki-Kataoka, Y., Yamagishi, H., Honjo, T. Proc. Natl. Acad. Sci. U.S.A. (1979)
- DNA rearrangements affecting both variable and constant regions of Ig H chain genes in MPC11 mouse myeloma variants. Gilmore, G.L., Bard, J.A., Birshtein, B.K. J. Immunol. (1988)
- Two distinct mechanisms of antitumor activity mediated by the combination of interleukin 2 and monoclonal antibodies. Vuist, W.M., van Buitenen, F., Hekman, A., Melief, C.J. Cancer Res. (1990)
- Dual roles for IFN-gamma, but not for IL-4, in spontaneous autoimmune thyroiditis in NOD.H-2h4 mice. Yu, S., Sharp, G.C., Braley-Mullen, H. J. Immunol. (2002)
- Hapten-induced model of murine inflammatory bowel disease: mucosa immune responses and protection by tolerance. Elson, C.O., Beagley, K.W., Sharmanov, A.T., Fujihashi, K., Kiyono, H., Tennyson, G.S., Cong, Y., Black, C.A., Ridwan, B.W., McGhee, J.R. J. Immunol. (1996)