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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Single- and multiple-dose pharmacokinetics of nufenoxole in healthy human subjects.

1. In 12 healthy subjects, after single doses of 20, 40 and 80 mg of nufenoxole, mean peak plasma drug concentrations of 400, 815 and 1463 ng/ml were reached at 2.2, 2.5 and 2.5 h respectively. 2. Nufenoxole was absorbed with an apparent half-life of less than one hour at all three doses. Nufenoxole concentrations declined biphasically after the peak, with an initial and terminal half-life of four to five hours and about 27 h respectively. These half-lives were independent of the administered dose. 3. AUC and Cmax increased with increasing dose, but AUC did not increase proportionately to dose, due to a lower value for 80 mg than expected, possibly reflecting reduced absorption. 4. Observed nufenoxole concentrations, in another 12 healthy subjects receiving single, daily 80 mg oral doses of nufenoxole for eight days, were in excellent agreement with those predicted from single-dose pharmacokinetics.[1]

References

  1. Single- and multiple-dose pharmacokinetics of nufenoxole in healthy human subjects. Brownsill, R.D., Hiley, M.P., Vose, C.W., Steiner, J.A., Stafford, J.E., McAllister, A., Rose, D.A., Gerry, N. Xenobiotica (1987) [Pubmed]
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