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Chemical Compound Review

Nufenoxol     7-[3-(5-methyl-1,3,4- oxadiazol-2-yl)-3,3...

Synonyms: Nufenoxole, Nufenoxolum, SureCN121031, Searle 27166, CHEMBL2106818, ...
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Psychiatry related information on SC 27166


High impact information on SC 27166


Biological context of SC 27166


Anatomical context of SC 27166

  • In the anesthetized dog, i.v. administration of morphine and SC-27166 enhanced the contractile activity of circular muscle in proximal and distal duodenum and distal ileum but duodenal longitudinal muscle was relaxed; these effects were completely reversed by subsequent administration of naloxone [1].
  • 6-keto PGF1 alpha and TXB2 synthesis by cultured colonic mucosa was also not affected by nufenoxole (50-800 ng/ml) [6].

Associations of SC 27166 with other chemical compounds


Analytical, diagnostic and therapeutic context of SC 27166

  • Supportive pharmacological studies indicated that SC-27166 has equivocal analgesia in mice which is manifested at near toxic dose levels [7].
  • SC-27166, which is chemically unrelated to opiates or neuroleptics, possesses potent constipating and antidiarrheal activity in several animal models [7].
  • 1. Nufenoxole, a novel antidiarrhoeal agent, was well absorbed in rat, monkey and human after oral administration [8].


  1. Antidiarrheal and central nervous system activities of SC-27166 (2-[3 - 5 - methyl - 1, 3, 4 - oxadiazol - 2 - yl) - 3, 3 - diphenylpropyl] - 2 - azabicyclo [2.2.2]octane), a new antidiarrheal agent, resulting from binding to opiate receptor sites of brain and myenteric plexus. Mackerer, C.R., Brougham, L.R., East, P.F., Bloss, J.L., Dajani, E.Z., Clay, G.A. J. Pharmacol. Exp. Ther. (1977) [Pubmed]
  2. Nufenoxole, a new antidiarrhoeal agent, inhibits fluid secretion in the human jejunum. Moriarty, K.J., Rolston, D.D., Kelly, M.J., Shield, M., Clark, M.L. Gut (1985) [Pubmed]
  3. Dependence liability of two antidiarrheals, nufenoxole and loperamide. Korey, A., Zilm, D.H., Sellers, E.M. Clin. Pharmacol. Ther. (1980) [Pubmed]
  4. Dissociation between opiate-like and antidiarrheal activities of antidiarrheal drugs. Niemegeers, C.J., McGuire, J.L., Heykants, J.J., Janssen, P.A. J. Pharmacol. Exp. Ther. (1979) [Pubmed]
  5. Single- and multiple-dose pharmacokinetics of nufenoxole in healthy human subjects. Brownsill, R.D., Hiley, M.P., Vose, C.W., Steiner, J.A., Stafford, J.E., McAllister, A., Rose, D.A., Gerry, N. Xenobiotica (1987) [Pubmed]
  6. Effect of nufenoxole on human colonic prostanoid synthesis, Na-K-ATPase and adenylate cyclase activities. Rachmilewitz, D., Karmeli, F. Eur. J. Pharmacol. (1984) [Pubmed]
  7. The pharmacology of SC-27166: a novel antidiarrheal agent. Dajani, E.Z., Bianchi, R.G., East, P.F., Bloss, J.L., Adelstein, G.W., Yen, C.H. J. Pharmacol. Exp. Ther. (1977) [Pubmed]
  8. Metabolism and pharmacokinetics of nufenoxole in animals and humans: an example of stereospecific hydroxylation of an isoquinuclidine ring. Cook, C.S., Campion, J.G., Hribar, J.D., Karim, A. Xenobiotica (1990) [Pubmed]
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