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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 

Correction of murine beta-thalassemia by gene transfer into the germ line.

A murine beta-thalassemia was corrected by the transfer of cloned beta-globin genes into the mouse germ line. The cloned mouse beta maj-globin gene or the cloned human beta-globin gene was introduced into mice deficient in beta-globin synthesis because of a deletion of the beta maj-globin gene. Both introduced genes produced functional beta-globin chains, leading to a reduction in one case, and elimination in another case, of the anemia and associated abnormalities of the red blood cells.[1]

References

  1. Correction of murine beta-thalassemia by gene transfer into the germ line. Costantini, F., Chada, K., Magram, J. Science (1986) [Pubmed]
 
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