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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Radiosensitizer conjugation to the carcinoma 19-9 monoclonal antibody.

Misonidazole was covalently conjugated (3-68 mol drug/ mol antibody) to 19-9 monoclonal antibody directed against a colorectal carcinoma tumor-associated antigen as a method for targeting radiosensitizing agents. This attachment was accomplished by the mixed anhydride method using the hemisuccinate derivative of misonidazole. Evaluation of conjugates in vitro shows a loss of antibody binding activity with increasing loading levels; however, significant binding activity is retained even at relatively high sensitizer/antibody ratios. This observation was consistent in three binding assays: a competitive radioimmunoassay; an enzyme immunoassay; and an affinity column assay. From these studies, it was concluded that the optimal loading factor for misonidazole-antibody conjugates, when it is used for immunochemotherapy lies between 8 and 15. In vitro release studies indicated that conjugates are hydrolytically stable (t1/2 = 4 days) under physiological conditions.[1]


  1. Radiosensitizer conjugation to the carcinoma 19-9 monoclonal antibody. Borlinghaus, K.P., Fitzpatrick, D.A., Heindel, N.D., Mattis, J.A., Mease, B.A., Schray, K.J., Shealy, D.J., Walton, H.L., Woo, D.V. Cancer Res. (1987) [Pubmed]
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