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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Tolerance and pilot pharmacokinetics of amiflamine after increasing single oral doses in healthy subjects.

Oral doses of 1 to 100 mg amiflamine, a new reversible monoamine oxidase type A-selective inhibitor, were given for the first time in humans to six healthy men. No apparent pharmacologic effects were recorded until the 80 mg dose. After 100 mg, one subject developed symptoms indicative of an overdose. Amiflamine is extensively metabolized by two consecutive N-demethylations. The biotransformation patterns in plasma and urine were found to correlate with the debrisoquin metabolic ratio.[1]

References

  1. Tolerance and pilot pharmacokinetics of amiflamine after increasing single oral doses in healthy subjects. Alván, G., Graffner, C., Grind, M., Gustafsson, L.L., Lindgren, J.E., Nordin, C., Ross, S., Selander, H., Siwers, B. Clin. Pharmacol. Ther. (1986) [Pubmed]
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