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Colaizzi, P.A. et al.

Comparative pharmacokinetics of azlocillin and piperacillin in normal adults.

The single-dose pharmacokinetics of azlocillin and piperacillin were compared by using a randomized, crossover design. The concentrations of azlocillin in serum were consistently higher than those of piperacillin throughout an 8-h study. The area under the time-concentration curve of azlocillin was significantly greater than that of piperacillin, and the total body clearance of azlocillin was significantly lower than that of piperacillin.[1]

References

Comparative pharmacokinetics of azlocillin and piperacillin in normal adults. Colaizzi, P.A., Polk, R.E., Poynor, W.J., Raffalovich, A.C., Cefali, E.A., Beightol, L.A. Antimicrob. Agents Chemother. (1986) [Pubmed]

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