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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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The failure of cyclosporin to inhibit granulomatous inflammation in acute Arthus-like panophthalmitis.

Acute Arthus-like panophthalmitis (AP) was induced in Lewis rat eyes by lens injury after immunization with whole rabbit lens extract. AP consists of an acute anterior ocular inflammation, followed by a posterior choroidal granulomatous reaction. Neither inflammatory response was inhibited by daily treatment with cyclosporin, 10 mg/kg, beginning on the day of lens injury. Cyclosporin would not be expected to interfere with the lens-induced anterior Arthus-like inflammation. The lack of inhibition of the choroidal inflammation was unexpected. The results are interpreted to indicate that the posterior granulomatous choroidal inflammation is a non-immune reaction initiated by the severe lens-induced Arthus-like reaction.[1]

References

  1. The failure of cyclosporin to inhibit granulomatous inflammation in acute Arthus-like panophthalmitis. Palestine, A.G., Chan, C.C., Gery, I., Nussenblatt, R.B. Immunol. Lett. (1985) [Pubmed]
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