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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Treatment of attention deficit disorder with DL-phenylalanine.

Nineteen patients meeting the criteria for attention deficit disorder, residual type (adult hyperactivity), were given a 2-week double-blind crossover of DL-phenylalanine versus placebo. Thirteen subjects completed the study; the mean global rating of improvement approached significance as compared with placebo. A significant improvement was noted on mood and mood lability. The phenylalanine responders were then continued on open drug, but lost all positive benefits within 3 months. A later open trial of L-phenylalanine produced no clinical effect.[1]


  1. Treatment of attention deficit disorder with DL-phenylalanine. Wood, D.R., Reimherr, F.W., Wender, P.H. Psychiatry research. (1985) [Pubmed]
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