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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Molecular genetics of the T cell-receptor beta chain.

Characterization of cDNA and genomic clones encoding the Beta chain of the T-cell receptor for antigen reveals a very close resemblance to immunoglobulin: V, D, J, and C elements; the mechanism of rearrangement; and the potential extent of diversity, explaining the relatively large T-cell repertoire of specificities and the clonal nature of individual responses. Differences with immunoglobulins are evident in the much more heterogeneous V beta sequences, which appear to have additional hypervariable regions. Together these data predict a roughly immunoglobulin-like structure for the receptor, but with potentially significant variation from immunoglobulin in the nature of the combining site(s).[1]


  1. Molecular genetics of the T cell-receptor beta chain. Davis, M.M. Annu. Rev. Immunol. (1985) [Pubmed]
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