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Gene Review

Tcrb  -  T cell receptor beta chain

Mus musculus

Synonyms: TCRbeta, Tib
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Disease relevance of Tcrb


High impact information on Tcrb


Biological context of Tcrb


Anatomical context of Tcrb


Associations of Tcrb with chemical compounds


Physical interactions of Tcrb


Regulatory relationships of Tcrb


Other interactions of Tcrb

  • Restoration of early thymocyte differentiation in T-cell receptor beta-chain-deficient mutant mice by transmembrane signaling through CD3 epsilon [29].
  • One of these haplotypes (Tcre alpha) appears to arise from a recombination between the Tcrb alpha and Tcra alpha haplotypes, the latter being the most frequently found in the conventional inbred strains [30].
  • Tcrb and Tcrg gene polymorphism was investigated in high (H) and low (L) responder Biozzi mice from selection I, II, and GS by Southern blot analysis with appropriate V and C probes [15].
  • None of the hybrids had rearranged the Tcrb gene cluster and 13 contained DJ rearrangements at the Igh locus [14].
  • The map location of this cluster between IgK and Tcrb coincides with the morphological mutation hypodactyly (Hd) [11].

Analytical, diagnostic and therapeutic context of Tcrb


  1. B-Cell deficiency predisposes mice to disseminating anaerobic infections: protection by passive antibody transfer. Hou, L., Sasakj, H., Stashenko, P. Infect. Immun. (2000) [Pubmed]
  2. Reciprocal stimulation of gammadelta T cells and dendritic cells during the anti-mycobacterial immune response. Dieli, F., Caccamo, N., Meraviglia, S., Ivanyi, J., Sireci, G., Bonanno, C.T., Ferlazzo, V., La Mendola, C., Salerno, A. Eur. J. Immunol. (2004) [Pubmed]
  3. Establishment of a Tcrb and Trp53 genes deficient mouse strain as an animal model for spontaneous colorectal cancer. Funabashi, H., Uchida, K., Kado, S., Matsuoka, Y., Ohwaki, M. Exp. Anim. (2001) [Pubmed]
  4. Locus controlling Bordetella pertussis-induced histamine sensitization (Bphs), an autoimmune disease-susceptibility gene, maps distal to T-cell receptor beta-chain gene on mouse chromosome 6. Sudweeks, J.D., Todd, J.A., Blankenhorn, E.P., Wardell, B.B., Woodward, S.R., Meeker, N.D., Estes, S.S., Teuscher, C. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  5. A large deletion within the T-cell receptor beta-chain gene complex in New Zealand white mice. Kotzin, B.L., Barr, V.L., Palmer, E. Science (1985) [Pubmed]
  6. Molecular genetics of the T cell-receptor beta chain. Davis, M.M. Annu. Rev. Immunol. (1985) [Pubmed]
  7. A novel disulfide-linked heterodimer on pre-T cells consists of the T cell receptor beta chain and a 33 kd glycoprotein. Groettrup, M., Ungewiss, K., Azogui, O., Palacios, R., Owen, M.J., Hayday, A.C., von Boehmer, H. Cell (1993) [Pubmed]
  8. Structure, organization, and somatic rearrangement of T cell gamma genes. Hayday, A.C., Saito, H., Gillies, S.D., Kranz, D.M., Tanigawa, G., Eisen, H.N., Tonegawa, S. Cell (1985) [Pubmed]
  9. The T cell receptor beta chain genes are located on chromosome 6 in mice and chromosome 7 in humans. Caccia, N., Kronenberg, M., Saxe, D., Haars, R., Bruns, G.A., Goverman, J., Malissen, M., Willard, H., Yoshikai, Y., Simon, M. Cell (1984) [Pubmed]
  10. Characterization of a newly discovered T-cell receptor beta-chain heterodimer expressed on a CD8+ bone marrow subpopulation that promotes allogeneic stem cell engraftment. Schuchert, M.J., Wright, R.D., Colson, Y.L. Nat. Med. (2000) [Pubmed]
  11. Genetic and cytogenetic localisation of the homeo box containing genes on mouse chromosome 6 and human chromosome 7. Bućan, M., Yang-Feng, T., Colberg-Poley, A.M., Wolgemuth, D.J., Guenet, J.L., Francke, U., Lehrach, H. EMBO J. (1986) [Pubmed]
  12. A role for MAPK in feedback inhibition of Tcrb recombination. Jackson, A.M., Krangel, M.S. J. Immunol. (2006) [Pubmed]
  13. Functional expression of a human TCR beta gene in transgenic mice. Rothe, J., Ryser, S., Mueller, U., Steinmetz, M., Bluethmann, H. Int. Immunol. (1993) [Pubmed]
  14. Rearrangement patterns of T-cell receptor genes in the spleen of athymic (nu/nu) young mice. Palacios, R., Samaridis, J. Immunogenetics (1991) [Pubmed]
  15. Polymorphism of Tcrb and Tcrg genes in Biozzi mice: segregation analysis of a new Tcrg haplotype with antibody responsiveness. Vidard, L., Roger, T., Pham, G., Couderc, J., Bouthillier, Y., Mevel, J.C., Mouton, D., Seman, M. Immunogenetics (1990) [Pubmed]
  16. The infection of mouse by Theiler's virus: from genetics to immunology. Monteyne, P., Bureau, J.F., Brahic, M. Immunol. Rev. (1997) [Pubmed]
  17. Cytolytic and IFN-gamma-producing activities of gamma delta T cells in the mouse intestinal epithelium are T cell receptor-beta-chain dependent. Kohyama, M., Nanno, M., Kawaguchi-Miyashita, M., Shimada, S., Watanabe, M., Hibi, T., Kaminogawa, S., Ishikawa, H. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  18. Intestinal microflora are necessary for development of spontaneous adenocarcinoma of the large intestine in T-cell receptor beta chain and p53 double-knockout mice. Kado, S., Uchida, K., Funabashi, H., Iwata, S., Nagata, Y., Ando, M., Onoue, M., Matsuoka, Y., Ohwaki, M., Morotomi, M. Cancer Res. (2001) [Pubmed]
  19. Pro-T cells in fetal thymus express c-kit and RAG-2 but do not rearrange the gene encoding the T cell receptor beta chain. Hozumi, K., Kobori, A., Sato, T., Nozaki, H., Nishikawa, S., Nishimura, T., Habu, S. Eur. J. Immunol. (1994) [Pubmed]
  20. Protein tyrosine kinase p56lck controls allelic exclusion of T-cell receptor beta-chain genes. Anderson, S.J., Levin, S.D., Perlmutter, R.M. Nature (1993) [Pubmed]
  21. A serine/threonine phosphorylation site in the ectodomain of a T cell receptor beta chain is required for activation by superantigen. Lukashev, D.E., Caldwell, C.C., Chen, P., Apasov, S.G., Margulies, D.H., Sitkovsky, M.V. J. Recept. Signal Transduct. Res. (2003) [Pubmed]
  22. A mutational analysis of the binding of staphylococcal enterotoxins B and C3 to the T cell receptor beta chain and major histocompatibility complex class II. Leder, L., Llera, A., Lavoie, P.M., Lebedeva, M.I., Li, H., Sékaly, R.P., Bohach, G.A., Gahr, P.J., Schlievert, P.M., Karjalainen, K., Mariuzza, R.A. J. Exp. Med. (1998) [Pubmed]
  23. Increased frequency of 2,4,6-trinitrophenyl (TNP)-specific, H-2b-restricted cytotoxic T lymphocyte precursors in transgenic mice expressing a T cell receptor beta chain gene from an H-2b-restricted, TNP-specific cytolytic T cell clone. Iglesias, A., Hansen-Hagge, T., Von Bonin, A., Weltzien, H.U. Eur. J. Immunol. (1992) [Pubmed]
  24. Establishment of a hemopoietic stimulating factor producing murine leukemia cell lines: pathogenesis of granulocytosis in L8313 bearing mice. Sawada, H., Itoh, K., Kirikae, T., Sakoda, H., Tezuka, H., Kuribayashi, K., Maeda, M., Yoshida, Y., Uchino, H., Hanaoka, M. Leuk. Res. (1988) [Pubmed]
  25. Linkage of regression and malignant conversion of rabbit viral papillomas to MHC class II genes. Han, R., Breitburd, F., Marche, P.N., Orth, G. Nature (1992) [Pubmed]
  26. Crucial role of the pre-T-cell receptor alpha gene in development of alpha beta but not gamma delta T cells. Fehling, H.J., Krotkova, A., Saint-Ruf, C., von Boehmer, H. Nature (1995) [Pubmed]
  27. Cell growth and gene rearrangement signals during the development of T lymphocytes within the thymus. Owen, J.J., Jenkinson, E.J., Kingston, R., Williams, G.T., Smith, C.A. Philos. Trans. R. Soc. Lond., B, Biol. Sci. (1990) [Pubmed]
  28. Superantigen-like effects and incidence of diabetes in NOD mice. McDuffie, M., Ostrowska, A. Diabetes (1993) [Pubmed]
  29. Restoration of early thymocyte differentiation in T-cell receptor beta-chain-deficient mutant mice by transmembrane signaling through CD3 epsilon. Levelt, C.N., Mombaerts, P., Iglesias, A., Tonegawa, S., Eichmann, K. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  30. Complexity, polymorphism, and recombination of mouse T-cell receptor alpha gene families. Jouvin-Marche, E., Morgado, M.G., Trede, N., Marche, P.N., Couez, D., Hue, I., Gris, C., Malissen, M., Cazenave, P.A. Immunogenetics (1989) [Pubmed]
  31. Donor gamma delta T lymphocytes promote allogeneic engraftment across the major histocompatibility barrier in mice. Drobyski, W.R., Majewski, D. Blood (1997) [Pubmed]
  32. Treatment with either anti-CD4 or anti-CD8 monoclonal antibodies blocks alphabeta T cell-mediated rejection of intestinal allografts in mice. Newell, K.A., He, G., Hart, J., Thistlethwaite, J.R. Transplantation (1997) [Pubmed]
  33. Giant cell vasculitis is a T cell-dependent disease. Brack, A., Geisler, A., Martinez-Taboada, V.M., Younge, B.R., Goronzy, J.J., Weyand, C.M. Mol. Med. (1997) [Pubmed]
  34. Characterization of expanded T cell clones in healthy macaques: ontogeny, distribution and stability. Nam, K.H., Illés, Z., Terao, K., Yoshikawa, Y., Yamamura, T. Dev. Comp. Immunol. (2000) [Pubmed]
  35. Expression of a transgenic T cell receptor beta chain enhances collagen-induced arthritis. Mori, L., Loetscher, H., Kakimoto, K., Bluethmann, H., Steinmetz, M. J. Exp. Med. (1992) [Pubmed]
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