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Wiener, J. et al.

Akinesia and mutism following a methylphenidate challenge test.

A case of akinesia and mutism is described in a menopausal, depressed woman with onset following a mood challenge with 40 mg of methylphenidate taken orally over a 3-hour period. Various diagnoses are considered with preference given on clinical grounds to conversion disorder precipitated by drug-induced dysphoria. It is suggested that increased susceptibility to dysphoria may have been related to prior clomipramine administration and hypoestrogenism.[1]

References

Akinesia and mutism following a methylphenidate challenge test. Wiener, J., Kennedy, S. Journal of clinical psychopharmacology. (1985) [Pubmed]

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