Genetic linkage of the cytolytic T lymphocyte repertoire and immunoglobulin heavy chain genes.
The specificity repertoire of H-2Kb-specific cytolytic T lymphocytes (CTL) has been examined in B10.D2,BALB/c, and the allotype congenic line CB-20. Comparing their expression of recurrent specificities that serve as markers for the repertoire of each strain indicates that the CTL repertoire of B10.D2 (Ighb) and BALB/c (Igha) differ extensively. In contrast, the repertoires expressed by B10.D2 and CB-20 (Ighb) are essentially identical with respect to their expression of the same recurrent specificities. Taken together with results previously obtained, it is concluded that both major histocompatibility complex and Igh-linked genes affect the CTL specificity repertoire.[1]References
- Genetic linkage of the cytolytic T lymphocyte repertoire and immunoglobulin heavy chain genes. Sherman, L.A. J. Exp. Med. (1982) [Pubmed]
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