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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Linkage (Genetics)

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Disease relevance of Linkage (Genetics)


Psychiatry related information on Linkage (Genetics)


High impact information on Linkage (Genetics)


Chemical compound and disease context of Linkage (Genetics)


Biological context of Linkage (Genetics)


Anatomical context of Linkage (Genetics)


Associations of Linkage (Genetics) with chemical compounds

  • Here we report tight genetic linkage between FALS and a gene that encodes a cytosolic, Cu/Zn-binding superoxide dismutase (SOD1), a homodimeric metalloenzyme that catalyzes the dismutation of the toxic superoxide anion O2.- to O2 and H2O2 (ref. 10) [31].
  • Transgenic mice were created to assess genetic linkage between Gerstmann-Sträussler-Scheinker syndrome and a leucine substitution at codon 102 of the human prion protein gene [32].
  • Immunologic properties of bacterial lipopolysaccharide (LPS). III. Genetic linkage between the in vitro mitogenic and in vivo adjuvant properties of LPS [33].
  • BACKGROUND: The alpha7 neuronal nicotinic acetylcholine receptor subunit gene (CHRNA7) has been implicated as a candidate gene for schizophrenia, and for an auditory sensory processing deficit found in the disease, by both genetic linkage at 15q14 and biochemical data [34].
  • The purpose of this study was to investigate genetic linkage between LDL size, TG, and related atherogenic lipoproteins and candidate genes known to be involved in lipid metabolism [35].

Gene context of Linkage (Genetics)

  • Close genetic linkage between HLA-B and 21-hydroxylase deficiency was thus established [36].
  • Genetic linkage and association studies have also shown that the epsilon4 allele of the apolipoprotein E (APOE) gene increases risk for AD in a dose-dependent manner in both familial and sporadic forms of AD and may account for as much as 50% of the attributable risk [37].
  • We have recently demonstrated tight genetic linkage between the type VII collagen gene (COL7A1) and both the dominant and recessive forms of dystrophic EB [38].
  • This information combined with the data generated by genetic linkage analysis demonstrated that the TCOF1 locus is closely flanked proximally by IG90 and distally by SPARC [39].
  • To evaluate the diagnostic and prognostic value of MEFV-gene analysis, we investigated 90 Armenian FMF patients from 77 unrelated families that were not selected through genetic-linkage analysis [40].

Analytical, diagnostic and therapeutic context of Linkage (Genetics)


  1. The molecular basis of the human serum paraoxonase activity polymorphism. Humbert, R., Adler, D.A., Disteche, C.M., Hassett, C., Omiecinski, C.J., Furlong, C.E. Nat. Genet. (1993) [Pubmed]
  2. An autoimmune disease-associated CTLA-4 splice variant lacking the B7 binding domain signals negatively in T cells. Vijayakrishnan, L., Slavik, J.M., Illés, Z., Greenwald, R.J., Rainbow, D., Greve, B., Peterson, L.B., Hafler, D.A., Freeman, G.J., Sharpe, A.H., Wicker, L.S., Kuchroo, V.K. Immunity (2004) [Pubmed]
  3. Failure of routine HIV-1 tests in a case involving transmission with preseroconversion blood components during the infectious window period. Ling, A.E., Robbins, K.E., Brown, T.M., Dunmire, V., Thoe, S.Y., Wong, S.Y., Leo, Y.S., Teo, D., Gallarda, J., Phelps, B., Chamberland, M.E., Busch, M.P., Folks, T.M., Kalish, M.L. JAMA (2000) [Pubmed]
  4. Compound heterozygosity for COL7A1 mutations in twins with dystrophic epidermolysis bullosa: a recessive paternal deletion/insertion mutation and a dominant negative maternal glycine substitution result in a severe phenotype. Christiano, A.M., Anton-Lamprecht, I., Amano, S., Ebschner, U., Burgeson, R.E., Uitto, J. Am. J. Hum. Genet. (1996) [Pubmed]
  5. A Bedouin kindred with infantile nephronophthisis demonstrates linkage to chromosome 9 by homozygosity mapping. Haider, N.B., Carmi, R., Shalev, H., Sheffield, V.C., Landau, D. Am. J. Hum. Genet. (1998) [Pubmed]
  6. Gilles de la Tourette syndrome is not linked to D2-dopamine receptor. Gelernter, J., Pakstis, A.J., Pauls, D.L., Kurlan, R., Gancher, S.T., Civelli, O., Grandy, D., Kidd, K.K. Arch. Gen. Psychiatry (1990) [Pubmed]
  7. Evidence for genetic linkage between a polymorphism in the adenosine 2A receptor and panic disorder. Hamilton, S.P., Slager, S.L., De Leon, A.B., Heiman, G.A., Klein, D.F., Hodge, S.E., Weissman, M.M., Fyer, A.J., Knowles, J.A. Neuropsychopharmacology (2004) [Pubmed]
  8. Molecular genetics of Alzheimer's disease and the amyloid beta peptide precursor gene. Tanzi, R.E. Ann. Med. (1989) [Pubmed]
  9. Association and linkage studies of candidate genes involved in GABAergic neurotransmission in lithium-responsive bipolar disorder. Duffy, A., Turecki, G., Grof, P., Cavazzoni, P., Grof, E., Joober, R., Ahrens, B., Berghöfer, A., Müller-Oerlinghausen, B., Dvoráková, M., Libigerová, E., Vojtĕchovský, M., Zvolský, P., Nilsson, A., Licht, R.W., Rasmussen, N.A., Schou, M., Vestergaard, P., Holzinger, A., Schumann, C., Thau, K., Robertson, C., Rouleau, G.A., Alda, M. Journal of psychiatry & neuroscience : JPN. (2000) [Pubmed]
  10. Clock gene polymorphisms and narcolepsy in positive and negative HLA-DQB1*0602 patients. Moreira, F., Pedrazzoli, M., Dos Santos Coelho, F.M., Pradella-Hallinan, M., Lopes da Conceição, M.C., Pereira Peregrino, A.J., de Oliveira, E.C., Tufik, S. Brain Res. Mol. Brain Res. (2005) [Pubmed]
  11. A second-generation screen of the human genome for susceptibility to insulin-dependent diabetes mellitus. Concannon, P., Gogolin-Ewens, K.J., Hinds, D.A., Wapelhorst, B., Morrison, V.A., Stirling, B., Mitra, M., Farmer, J., Williams, S.R., Cox, N.J., Bell, G.I., Risch, N., Spielman, R.S. Nat. Genet. (1998) [Pubmed]
  12. A genetic linkage map of the Syrian hamster and localization of cardiomyopathy locus on chromosome 9qa2.1-b1 using RLGS spot-mapping. Okazaki, Y., Okuizumi, H., Ohsumi, T., Nomura, O., Takada, S., Kamiya, M., Sasaki, N., Matsuda, Y., Nishimura, M., Tagaya, O., Muramatsu, M., Hayashizaki, Y. Nat. Genet. (1996) [Pubmed]
  13. Absence of association or genetic linkage between the angiotensin-converting-enzyme gene and left ventricular mass. Cambien, F., Tiret, L. N. Engl. J. Med. (1996) [Pubmed]
  14. SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome. Wang, Q., Shen, J., Splawski, I., Atkinson, D., Li, Z., Robinson, J.L., Moss, A.J., Towbin, J.A., Keating, M.T. Cell (1995) [Pubmed]
  15. Dihydropyridine receptor mutations cause hypokalemic periodic paralysis. Ptácek, L.J., Tawil, R., Griggs, R.C., Engel, A.G., Layzer, R.B., Kwieciński, H., McManis, P.G., Santiago, L., Moore, M., Fouad, G. Cell (1994) [Pubmed]
  16. Two genes encoding steroid 21-hydroxylase are located near the genes encoding the fourth component of complement in man. White, P.C., Grossberger, D., Onufer, B.J., Chaplin, D.D., New, M.I., Dupont, B., Strominger, J.L. Proc. Natl. Acad. Sci. U.S.A. (1985) [Pubmed]
  17. Pretibial epidermolysis bullosa: genetic linkage to COL7A1 and identification of a glycine-to-cysteine substitution in the triple-helical domain of type VII collagen. Christiano, A.M., Lee, J.Y., Chen, W.J., LaForgia, S., Uitto, J. Hum. Mol. Genet. (1995) [Pubmed]
  18. Transposon-encoded sucrose metabolism in Lactococcus lactis. Purification of sucrose-6-phosphate hydrolase and genetic linkage to N5-(L-1-carboxyethyl)-L-ornithine synthase in strain K1. Thompson, J., Nguyen, N.Y., Sackett, D.L., Donkersloot, J.A. J. Biol. Chem. (1991) [Pubmed]
  19. Deficient nifedipine oxidation: a rare inherited trait associated with cystic fibrosis kindreds. Daly, A.K., Salh, B.S., Bilton, D., Allen, J., Knight, A.D., Webb, A.K., Braganza, J.M., Idle, J.R. Pharmacogenetics (1992) [Pubmed]
  20. Blunted renal vascular response to angiotensin II is associated with a common variant of the angiotensinogen gene and obesity. Hopkins, P.N., Lifton, R.P., Hollenberg, N.K., Jeunemaitre, X., Hallouin, M.C., Skuppin, J., Williams, C.S., Dluhy, R.G., Lalouel, J.M., Williams, R.R., Williams, G.H. J. Hypertens. (1996) [Pubmed]
  21. Localization of a gene for Fukuyama type congenital muscular dystrophy to chromosome 9q31-33. Toda, T., Segawa, M., Nomura, Y., Nonaka, I., Masuda, K., Ishihara, T., Sakai, M., Tomita, I., Origuchi, Y., Suzuki M [corrected to Sakai, M. Nat. Genet. (1993) [Pubmed]
  22. Close genetic linkage between X-linked retinitis pigmentosa and a restriction fragment length polymorphism identified by recombinant DNA probe L1.28. Bhattacharya, S.S., Wright, A.F., Clayton, J.F., Price, W.H., Phillips, C.I., McKeown, C.M., Jay, M., Bird, A.C., Pearson, P.L., Southern, E.M. Nature (1984) [Pubmed]
  23. Linkage of high-affinity IgE receptor gene with bronchial hyperreactivity, even in absence of atopy. van Herwerden, L., Harrap, S.B., Wong, Z.Y., Abramson, M.J., Kutin, J.J., Forbes, A.B., Raven, J., Lanigan, A., Walters, E.H. Lancet (1995) [Pubmed]
  24. A genetic linkage map of 27 loci from PND to FY on the short arm of human chromosome I. Dracopoli, N.C., Stanger, B.Z., Ito, C.Y., Call, K.M., Lincoln, S.E., Lander, E.S., Housman, D.E. Am. J. Hum. Genet. (1988) [Pubmed]
  25. A cluster of highly polymorphic dinucleotide repeats in intron 17b of the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Zielenski, J., Markiewicz, D., Rininsland, F., Rommens, J., Tsui, L.C. Am. J. Hum. Genet. (1991) [Pubmed]
  26. Restricted heterogeneity of T cell receptor transcripts in rheumatoid synovium. Williams, W.V., Fang, Q., Demarco, D., VonFeldt, J., Zurier, R.B., Weiner, D.B. J. Clin. Invest. (1992) [Pubmed]
  27. Products, genetic linkage and limb patterning activity of a murine hedgehog gene. Chang, D.T., López, A., von Kessler, D.P., Chiang, C., Simandl, B.K., Zhao, R., Seldin, M.F., Fallon, J.F., Beachy, P.A. Development (1994) [Pubmed]
  28. Andersen's syndrome: a distinct periodic paralysis. Sansone, V., Griggs, R.C., Meola, G., Ptácek, L.J., Barohn, R., Iannaccone, S., Bryan, W., Baker, N., Janas, S.J., Scott, W., Ririe, D., Tawil, R. Ann. Neurol. (1997) [Pubmed]
  29. cDNA cloning of mouse NKR-P1 and genetic linkage with LY-49. Identification of a natural killer cell gene complex on mouse chromosome 6. Yokoyama, W.M., Ryan, J.C., Hunter, J.J., Smith, H.R., Stark, M., Seaman, W.E. J. Immunol. (1991) [Pubmed]
  30. Functional impact of human collagen alpha2(XI) gene polymorphism in pathogenesis of ossification of the posterior longitudinal ligament of the spine. Maeda, S., Ishidou, Y., Koga, H., Taketomi, E., Ikari, K., Komiya, S., Takeda, J., Sakou, T., Inoue, I. J. Bone Miner. Res. (2001) [Pubmed]
  31. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Rosen, D.R., Siddique, T., Patterson, D., Figlewicz, D.A., Sapp, P., Hentati, A., Donaldson, D., Goto, J., O'Regan, J.P., Deng, H.X. Nature (1993) [Pubmed]
  32. Spontaneous neurodegeneration in transgenic mice with mutant prion protein. Hsiao, K.K., Scott, M., Foster, D., Groth, D.F., DeArmond, S.J., Prusiner, S.B. Science (1990) [Pubmed]
  33. Immunologic properties of bacterial lipopolysaccharide (LPS). III. Genetic linkage between the in vitro mitogenic and in vivo adjuvant properties of LPS. Skidmore, B.J., Chiller, J.M., Weigle, W.O., Riblet, R., Watson, J. J. Exp. Med. (1976) [Pubmed]
  34. Association of promoter variants in the alpha7 nicotinic acetylcholine receptor subunit gene with an inhibitory deficit found in schizophrenia. Leonard, S., Gault, J., Hopkins, J., Logel, J., Vianzon, R., Short, M., Drebing, C., Berger, R., Venn, D., Sirota, P., Zerbe, G., Olincy, A., Ross, R.G., Adler, L.E., Freedman, R. Arch. Gen. Psychiatry (2002) [Pubmed]
  35. Candidate-gene studies of the atherogenic lipoprotein phenotype: a sib-pair linkage analysis of DZ women twins. Austin, M.A., Talmud, P.J., Luong, L.A., Haddad, L., Day, I.N., Newman, B., Edwards, K.L., Krauss, R.M., Humphries, S.E. Am. J. Hum. Genet. (1998) [Pubmed]
  36. Genetic mapping of the 21-hydroxylase-deficiency gene within the HLA linkage group. Levine, L.S., Zachmann, M., New, M.I., Prader, A., Pollack, M.S., O'Neill, G.J., Yang, S.Y., Oberfield, S.E., Dupont, B. N. Engl. J. Med. (1978) [Pubmed]
  37. Exploring the etiology of Alzheimer disease using molecular genetics. Lendon, C.L., Ashall, F., Goate, A.M. JAMA (1997) [Pubmed]
  38. Dominant dystrophic epidermolysis bullosa: identification of a Gly-->Ser substitution in the triple-helical domain of type VII collagen. Christiano, A.M., Ryynänen, M., Uitto, J. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  39. Narrowing the position of the Treacher Collins syndrome locus to a small interval between three new microsatellite markers at 5q32-33.1. Dixon, M.J., Dixon, J., Houseal, T., Bhatt, M., Ward, D.C., Klinger, K., Landes, G.M. Am. J. Hum. Genet. (1993) [Pubmed]
  40. MEFV-Gene analysis in armenian patients with Familial Mediterranean fever: diagnostic value and unfavorable renal prognosis of the M694V homozygous genotype-genetic and therapeutic implications. Cazeneuve, C., Sarkisian, T., Pêcheux, C., Dervichian, M., Nédelec, B., Reinert, P., Ayvazyan, A., Kouyoumdjian, J.C., Ajrapetyan, H., Delpech, M., Goossens, M., Dodé, C., Grateau, G., Amselem, S. Am. J. Hum. Genet. (1999) [Pubmed]
  41. The diagnosis and prognosis of autosomal dominant polycystic kidney disease. Parfrey, P.S., Bear, J.C., Morgan, J., Cramer, B.C., McManamon, P.J., Gault, M.H., Churchill, D.N., Singh, M., Hewitt, R., Somlo, S. N. Engl. J. Med. (1990) [Pubmed]
  42. Prenatal diagnosis and a donor splice site mutation in fibrillin in a family with Marfan syndrome. Godfrey, M., Vandemark, N., Wang, M., Velinov, M., Wargowski, D., Tsipouras, P., Han, J., Becker, J., Robertson, W., Droste, S. Am. J. Hum. Genet. (1993) [Pubmed]
  43. Gain of function mutation in the mineralocorticoid receptor of the Brown Norway rat. Marissal-Arvy, N., Lombès, M., Petterson, J., Moisan, M.P., Mormède, P. J. Biol. Chem. (2004) [Pubmed]
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