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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Expression of a chemically synthesized human alpha 1 interferon gene.

Cells of Escherichia coli containing a chemically synthesized human alpha 1 interferon (IFN-alpha 1) gene, under control of the lac promoter, make a product with biological properties indistinguishable from those of the natural IFN-alpha 1 [antiviral activity, acid stability, species crossreactivity, inactivation by antisera directed against leukocyte or Namalwa cell interferon, and stimulation of (2'-5')oligoadenylate synthetase activity]. Similar levels of IFN synthesis were obtained when the expression unit (lac promoter plus synthetic IFN-alpha 1 gene) was transplanted into the obligate methylotroph Methylophilus methylotrophus.[1]

References

  1. Expression of a chemically synthesized human alpha 1 interferon gene. De Maeyer, E., Skup, D., Prasad, K.S., De Maeyer-Guignard, J., Williams, B., Meacock, P., Sharpe, G., Pioli, D., Hennam, J., Schuch, W., Atherton, K. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
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