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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

PBB inhibits metabolic cooperation in Chinese hamster cells in vitro: its potential as a tumor promoter.

Using an in vitro assay system, polybrominated biphenyl (PBB) was assessed for its ability to inhibit metabolic cooperation between 6-thioguanine sensitive and resistant Chinese hamster V79 cells. Using a nonlethal range of the chemical, PBB was shown to inhibit metabolic cooperation (a form of cell-cell communication) in a manner similar to other known tumor promoters. Results suggest that PBB could act, epigenetically, as a teratogen and a carcinogenic promoter.[1]

References

  1. PBB inhibits metabolic cooperation in Chinese hamster cells in vitro: its potential as a tumor promoter. Trosko, J.E., Dawson, B., Chang, C.C. Environ. Health Perspect. (1981) [Pubmed]
 
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