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Chemical Compound Review

CCRIS 312     1,2,4-tribromo-5-(2,4,5...

Synonyms: CCRIS 5773, AG-G-10067, HSDB 2913, HSDB 7064, LS-1573, ...
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Disease relevance of Polybrominated biphenyls


High impact information on Polybrominated biphenyls


Chemical compound and disease context of Polybrominated biphenyls


Biological context of Polybrominated biphenyls


Anatomical context of Polybrominated biphenyls


Associations of Polybrominated biphenyls with other chemical compounds


Gene context of Polybrominated biphenyls

  • Penta-, hexa-, and hepta-bromobiphenyl components in serum samples analyzed from farming families from Michigan Chemical Corporation employees were compared with relative concentrations of these homologs in FireMaster mixture and in tissue and blood samples from rats fed FireMaster FF-1 [25].
  • The effect of polybrominated biphenyl (PBB) in testes, adrenal, and pituitary function in the rat [26].
  • Reductive debromination of the commercial polybrominated biphenyl mixture firemaster BP6 by anaerobic microorganisms from sediments [27].
  • Male, albino rats of the F-344/N strain and mice of the B6C3F1 strain were dosed by gavage, 5 days per week for a toal of 22 doses with 0.03--30 mg/kg of FireMaster FF-1, 0.168-16.8 Mg/kg of 2,4,5,2',4',5'-hexabromobiphenyl (HBB), or corn oil vehicle [28].
  • For this purpose, the technical hexabromobiphenyl product Firemaster BP-6 was characterised by gas-chromatography coupled to electron capture detection (GC/ECD) and electron-capture negative ion mass spectrometry (GC/ECNI-MS) as well as by liquid chromatographic fractionating on active carbon and celite [29].

Analytical, diagnostic and therapeutic context of Polybrominated biphenyls


  1. Toxicity of polybrominated biphenyl. Kimbrough, R.D., Burse, V.W., Liddle, J.A. Lancet (1977) [Pubmed]
  2. Sequential study on the synergistic effects of 2,2',4,4',5,5'-hexabromobiphenyl and 3,3',4,4',5,5'-hexabromobiphenyl on hepatic tumor promotion. Jensen, R.K., Sleight, S.D. Carcinogenesis (1986) [Pubmed]
  3. Cancer among a Michigan cohort exposed to polybrominated biphenyls in 1973. Hoque, A., Sigurdson, A.J., Burau, K.D., Humphrey, H.E., Hess, K.R., Sweeney, A.M. Epidemiology (Cambridge, Mass.) (1998) [Pubmed]
  4. Breast cancer among women exposed to polybrominated biphenyls. Henderson, A.K., Rosen, D., Miller, G.L., Figgs, L.W., Zahm, S.H., Sieber, S.M., Rothman, N., Humphrey, H.E., Sinks, T. Epidemiology (Cambridge, Mass.) (1995) [Pubmed]
  5. Immunochemical quantitation of cytochrome P-450 isozymes and epoxide hydrolase in liver microsomes from polychlorinated or polybrominated biphenyl-treated rats. A study of structure-activity relationships. Parkinson, A., Safe, S.H., Robertson, L.W., Thomas, P.E., Ryan, D.E., Reik, L.M., Levin, W. J. Biol. Chem. (1983) [Pubmed]
  6. Regulation of glycogen content in primary astrocyte culture: effects of glucose analogues, phenobarbital, and methionine sulfoximine. Swanson, R.A., Yu, A.C., Sharp, F.R., Chan, P.H. J. Neurochem. (1989) [Pubmed]
  7. Half-life of polybrominated biphenyl in human sera. Rosen, D.H., Flanders, W.D., Friede, A., Humphrey, H.E., Sinks, T.H. Environ. Health Perspect. (1995) [Pubmed]
  8. Vitamin A status, polybrominated biphenyl (PBB) toxicosis, and common bile duct hyperplasia in rats. Darjono, n.u.l.l., Sleight, S.D., Stowe, H.D., Aust, S.D. Toxicol. Appl. Pharmacol. (1983) [Pubmed]
  9. Stunted growth, increased mortality, and liver tumors in offspring of polybrominated biphenyl (PBB) dosed sherman rats. Groce, D.F., Kimbrough, R.D. Journal of toxicology and environmental health. (1984) [Pubmed]
  10. Spermatogenesis in men exposed to polybrominated biphenyl (PBB). Rosenman, K.D., Anderson, H.A., Selikoff, I.J., Wolff, M.S., Holstein, E. Fertil. Steril. (1979) [Pubmed]
  11. On-site polymer-coated hollow fiber membrane microextraction and gas chromatography-mass spectrometry of polychlorinated biphenyls and polybrominated diphenyl ethers. Basheer, C., Vetrichelvan, M., Valiyaveettil, S., Lee, H.K. Journal of chromatography. A (2007) [Pubmed]
  12. Polybrominated biphenyl exposure and human cancer: report of a case and public health implications. Sherman, J.D. Toxicology and industrial health. (1991) [Pubmed]
  13. Differential tissue distribution of various polybrominated biphenyls of Firemaster FF-1 in male rats. Domino, E.F., Fivenson, D.P., Domino, S.E. Drug Metab. Dispos. (1980) [Pubmed]
  14. 2,2',4,4',5,5'-hexabromobiphenyl: its toxicokinetics, biotransformation and porphyrinogenic action in rats. Koss, G., Weider, T., Seubert, S., Seubert, A. Food Chem. Toxicol. (1994) [Pubmed]
  15. Regulation of cytochrome P-450. Immunochemical quantitation of eight isozymes in liver microsomes of rats treated with polybrominated biphenyl congeners. Dannan, G.A., Guengerich, F.P., Kaminsky, L.S., Aust, S.D. J. Biol. Chem. (1983) [Pubmed]
  16. PBB fed to adult female chickens: its effect on egg production, reproduction, viability of offspring, and residues in tissues and eggs. Polin, D., Ringer, R.K. Environ. Health Perspect. (1978) [Pubmed]
  17. Studies on the microsomal metabolism and binding of polybrominated biphenyls (PBBs). Dannan, G.A., Moore, R.W., Aust, S.D. Environ. Health Perspect. (1978) [Pubmed]
  18. EM changes and other toxic effects of firemaster BP-6 (polybrominated biphenyls) in the mouse. Corbett, T.H., Simmons, J.L., Kawanishi, H., Endres, J.L. Environ. Health Perspect. (1978) [Pubmed]
  19. Toxicity of firemaster FF-1 and 2,2',4,4',5,5'-hexabromobiphenyl in cultures of C3H/10T 1/2 mammalian fibroblasts. Bairstow, F., Hsia, M.T., Norback, D.H., Allen, J.R. Environ. Health Perspect. (1978) [Pubmed]
  20. PBB inhibits metabolic cooperation in Chinese hamster cells in vitro: its potential as a tumor promoter. Trosko, J.E., Dawson, B., Chang, C.C. Environ. Health Perspect. (1981) [Pubmed]
  21. Multi-residue screening of chlorinated and brominated compounds from aquaculture samples using matrix solid-phase dispersion--gas chromatography-mass spectrometry. Carro, A.M., Lorenzo, R.A., Fernández, F., Rodil, R., Cela, R. Journal of chromatography. A. (2005) [Pubmed]
  22. Comparisons of warfarin metabolism by liver microsomes of rats treated with a series of polybrominated biphenyl congeners and by the component-purified cytochrome P-450 isozymes. Kaminsky, L.S., Guengerich, F.P., Dannan, G.A., Aust, S.D. Arch. Biochem. Biophys. (1983) [Pubmed]
  23. Ornithine decarboxylase, serum isocitrate dehydrogenase and clinical chemistry changes during thioacetamide-induced hepatotoxicity in a calf. Schanbacher, F.L., Willett, L.B., Moorhead, P.D. J. Anim. Sci. (1981) [Pubmed]
  24. Polybrominated diphenyl ethers and traditional organochlorine pollutants in fulmars (Fulmarus glacialis) from the Faroe Islands. Fängström, B., Athanasiadou, M., Athanassiadis, I., Bignert, A., Grandjean, P., Weihe, P., Bergman, A. Chemosphere (2005) [Pubmed]
  25. PBB homologs in sera of Michigan dairy farmers and Michigan chemical workers. Wolff, M.S., Aubrey, B. Environ. Health Perspect. (1978) [Pubmed]
  26. The effect of polybrominated biphenyl (PBB) in testes, adrenal, and pituitary function in the rat. Castracane, V.D., Allen-Rowlands, C.F., Hamilton, M.G., Seifter, J. Proc. Soc. Exp. Biol. Med. (1982) [Pubmed]
  27. Reductive debromination of the commercial polybrominated biphenyl mixture firemaster BP6 by anaerobic microorganisms from sediments. Morris, P.J., Quensen, J.F., Tiedje, J.M., Boyd, S.A. Appl. Environ. Microbiol. (1992) [Pubmed]
  28. Behavioral and neurological toxicity of polybrominated biphenyls in rats and mice. Tilson, H.A., Cabe, P.A., Mitchell, C.L. Environ. Health Perspect. (1978) [Pubmed]
  29. Chromatographic enrichment and enantiomer separation of axially chiral polybrominated biphenyls in a technical mixture. Berger, U., Vetter, W., Götsch, A., Kallenborn, R. Journal of chromatography. A. (2002) [Pubmed]
  30. Persistence of polybrominated biphenyls (PBB) in human post-mortem tissue. Miceli, J.N., Nolan, D.C., Marks, B., Hariharan, M. Environ. Health Perspect. (1985) [Pubmed]
  31. Investigation of hyperkeratotic activity of polybrominated biphenyls in Firemaster FF-1. Needham, L.L., Hill, R.H., Orti, D.L., Patterson, D.G., Kimbrough, R.D., Groce, D.F., Liddle, J.A. Journal of toxicology and environmental health. (1982) [Pubmed]
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