Disease relevance of Polybrominated biphenyls

• Toxicity of polybrominated biphenyl [1].
• A sequential study was completed to determine the effect of polybrominated biphenyl (PBB) congeners on the enhancement of gamma-glutamyl transpeptidase (GGT)-positive altered hepatic foci (AHF) and the development of hepatic nodules (HN) and carcinomas [2].
• Univariate analysis for polybrominated biphenyl level and lymphoma risk also showed a dose-response relation, with corresponding ORs of 3.24 (95% CI = 0.24-95.9), 20.5 (95% CI = 1.51-608), and 32.6 (95% CI = 3.33-861) [3].
• We conducted a nested case-control study with 1,925 women enrolled in a polybrominated biphenyl (PBB) registry to examine the association between breast cancer and serum PBBs [4].
• We found an increasing dose-response relation for digestive system cancer risk with higher serum polybrominated biphenyl category [4-20 parts per billion (ppb), 21-50 ppb, and > 50 ppb] after adjustment for age, family cancer history, cigarette smoking, alcohol drinking, and baseline serum polychlorinated biphenyl level [3].

High impact information on Polybrominated biphenyls

• Immunochemical quantitation of cytochrome P-450 isozymes and epoxide hydrolase in liver microsomes from polychlorinated or polybrominated biphenyl-treated rats. A study of structure-activity relationships [5].
• The phosphorylase b inhibitors 2,2',4,4',5,5'-hexabromobiphenyl and riboflavin had no effect on astrocyte glycogen content, consistent with negligible phosphorylase b activity in normal astrocytes [6].
• In this nested case-control study, we evaluated the association between site-specific cancer risk and serum polybrominated biphenyl levels among a Michigan cohort accidentally exposed to polybrominated biphenyls in 1973 [3].
• Polybrominated biphenyl (PBB), a flame-retardant material, was introduced into the food chain in Michigan in 1973 due to a manufacturing and distribution mistake [7].
• Half-life of polybrominated biphenyl in human sera [7].

Chemical compound and disease context of Polybrominated biphenyls

• Vitamin A status, polybrominated biphenyl (PBB) toxicosis, and common bile duct hyperplasia in rats [8].
• Firemaster FF-1, a polybrominated biphenyl (PBB) mixture, was dissolved in corn oil and given as a dose of 200 mg/kg body weight to Sherman rats on d 7 and 14 of pregnancy [9].

Biological context of Polybrominated biphenyls

• Spermatogenesis in men exposed to polybrominated biphenyl (PBB) [10].
• Porous polypropylene hollow fiber membrane coated with a conjugated polymer was used as an on-site sampling device for the extraction of polychlorinated biphenyls and polybrominated biphenyl ethers from coastal sea water samples [11].
• Polybrominated biphenyl exposure and human cancer: report of a case and public health implications [12].
• Differential tissue distribution of various polybrominated biphenyls of Firemaster FF-1 in male rats [13].
• 2,2',4,4',5,5'-hexabromobiphenyl: its toxicokinetics, biotransformation and porphyrinogenic action in rats [14].

Anatomical context of Polybrominated biphenyls

• Regulation of cytochrome P-450. Immunochemical quantitation of eight isozymes in liver microsomes of rats treated with polybrominated biphenyl congeners [15].
• Dose--response lines are presented for PBB in muscle, liver, kidney, adipose tissue, and eggs [16].
• When a 14C-PBB mixture consisting almost exclusively of peaks 4 (2,4,5,2',4',5'-hexabromobiphenyl) and 8 (2,3,4,5,2',4',5'-heptabromobiphenyl) was incubated with PB- or PBBs- induced microsomes and NADPH, only traces of radioactivity remained with the microsomes after extensive extraction [17].
• Twelve weeks post-feeding, the tissue concentrations of hexabromobiphenyl in order of highest concentration to lowest were as follows: perithymic fat, perirenal fat, adrenal glands, thymus gland, liver and stomach [18].
• Toxicity of firemaster FF-1 and 2,2',4,4',5,5'-hexabromobiphenyl in cultures of C3H/10T 1/2 mammalian fibroblasts [19].

Associations of Polybrominated biphenyls with other chemical compounds

• Using an in vitro assay system, polybrominated biphenyl (PBB) was assessed for its ability to inhibit metabolic cooperation between 6-thioguanine sensitive and resistant Chinese hamster V79 cells [20].
• An effective multiresidual method for the trace analysis of fifteen compounds from a diverse group of pesticides, polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyl (PCBs) and polybrominated biphenyl (PBBs) in aquaculture feed is described [21].
• R- and S-warfarin metabolite profiles (regio- and stereoselectivity) has been determined with hepatic microsomes from untreated rats and rats treated with nine individual polybrominated biphenyl (PBB) congeners, a commercial mixture of PBBs, and, for comparison with phenobarbital and 3-methylcholanthrene [22].
• Our previous studies showed that polybrominated biphenyl (PBB) induced hepatic microsomal cytochrome P-450 in dairy cattle but did not elevate hepatic cytosolic ornithine decarboxylase or serum isocitrate dehydrogenase [23].
• For the polybrominated biphenyl (BB-153) the concentrations are considerably higher in the adult bird and egg than in the juvenile bird; this is also seen for the PCB and 4,4'-DDE concentrations [24].

Gene context of Polybrominated biphenyls

• Penta-, hexa-, and hepta-bromobiphenyl components in serum samples analyzed from farming families from Michigan Chemical Corporation employees were compared with relative concentrations of these homologs in FireMaster mixture and in tissue and blood samples from rats fed FireMaster FF-1 [25].
• The effect of polybrominated biphenyl (PBB) in testes, adrenal, and pituitary function in the rat [26].
• Reductive debromination of the commercial polybrominated biphenyl mixture firemaster BP6 by anaerobic microorganisms from sediments [27].
• Male, albino rats of the F-344/N strain and mice of the B6C3F1 strain were dosed by gavage, 5 days per week for a toal of 22 doses with 0.03--30 mg/kg of FireMaster FF-1, 0.168-16.8 Mg/kg of 2,4,5,2',4',5'-hexabromobiphenyl (HBB), or corn oil vehicle [28].
• For this purpose, the technical hexabromobiphenyl product Firemaster BP-6 was characterised by gas-chromatography coupled to electron capture detection (GC/ECD) and electron-capture negative ion mass spectrometry (GC/ECNI-MS) as well as by liquid chromatographic fractionating on active carbon and celite [29].

Analytical, diagnostic and therapeutic context of Polybrominated biphenyls

• Samples of 196 tissues from 15 subjects were analyzed for PBB content, and levels were determined by measurement of the hexabromobiphenyl peak using electron capture gas chromatography [30].
• A procedure for purifying 2,2', 4,4',5,5'-hexabromobiphenyl (HBB) from FireMaster FF-1 in gram amounts by crystallization is presented [19].
• Experience with other halogenated hydrocarbons, animal experiments, and individual complaints indicated that polybrominated biphenyl (PBB) might have an effect on human spermatogenesis [10].
• A polybrominated biphenyl (PBB) mixture was fractionated by normal-phase preparative high-performance liquid chromatography [31].

References