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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Epinephrine reduction of heme: implication for understanding the transmission of an agonist stimulus.

Alpha-adrenergic agonists that promote platelet aggregation were found to reduce ferric heme to ferrous heme. Agents that bind iron in heme inhibited epinephrine-induced platelet aggregation. It is proposed that epinephrine first binds to its receptor and then reduces an adjacent heme group to transmit its agonist stimulus.[1]

References

  1. Epinephrine reduction of heme: implication for understanding the transmission of an agonist stimulus. Peterson, D.A., Gerrard, J.M., Glover, S.M., Rao, G.H., White, J.G. Science (1982) [Pubmed]
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