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Chemical Compound Review

Racepinephrine     4-(1-hydroxy-2-methylamino- ethyl)benzene-1...

Synonyms: Epinephrin, Epirenamine, Epinepherine, Racepinefrina, Racepinefrine, ...
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Disease relevance of Vaponefrin


Psychiatry related information on Vaponefrin


High impact information on Vaponefrin


Chemical compound and disease context of Vaponefrin


Biological context of Vaponefrin

  • The lowest concentration of these agents required to produce biphasic platelet aggregation decreased (i.e., aggregability increased) from a mean +/- SEM of 4.7 +/- 0.6 to 3.7 +/- 0.6 microM (P less than 0.01) for ADP and from 3.7 +/- 0.8 to 1.8 +/- 0.5 microM (P less than 0.01) for epinephrine [21].
  • In all three groups, systolic and diastolic pressure rose markedly, the plasma epinephrine level increased by 50 to 150 pg per milliliter, and the norepinephrine level by 100 to 200 pg per milliliter under both stress conditions (P less than 0.001) [22].
  • Platelets in essential thrombocythemia demonstrated normal kinetics of 3H-DHE binding and normal affinities for 3H-DHE and for epinephrine [23].
  • The acute effects of intravenous somatostatin (0.8 micrograms per kilogram per minute for two hours) in previously untreated animals transiently decreased platelet count, reduced retention of platelets on glass-bead columns and inhibited aggregation induced by ADP, collagen and epinephrine [24].
  • Acetylsalicylic acid was shown both in vivo and in vitro to prevent the platelet lipid peroxidation normally induced by the aggregating agents thrombin and epinephrine, and the sulfhydryl inhibitor N-ethylmaleimide [25].

Anatomical context of Vaponefrin


Associations of Vaponefrin with other chemical compounds


Gene context of Vaponefrin


Analytical, diagnostic and therapeutic context of Vaponefrin

  • High-dose epinephrine in cardiopulmonary resuscitation [41].
  • Factors that predicted survival to hospital discharge included a short interval between the arrest and arrival at the hospital, a palpable pulse on presentation, a short duration of resuscitation in the emergency department, and the administration of fewer doses of epinephrine in the emergency department [42].
  • To study these responses, we administered epinephrine in a graded intravenous infusion (0.5 to 5 micrograms per minute) to seven diabetic patients without neuropathy, seven diabetic patients with autonomic neuropathy, and seven normal subjects [43].
  • Patients with actively bleeding ulcers or ulcers with nonbleeding visible vessels were treated with an epinephrine injection followed by thermocoagulation [44].
  • We randomly assigned 3327 patients to receive up to 15 high doses (5 mg each) or standard doses (1 mg each) of epinephrine according to the current protocol for advanced cardiac life support [3].


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  11. Adrenomedullary dysplasia and hypofunction in patients with classic 21-hydroxylase deficiency. Merke, D.P., Chrousos, G.P., Eisenhofer, G., Weise, M., Keil, M.F., Rogol, A.D., Van Wyk, J.J., Bornstein, S.R. N. Engl. J. Med. (2000) [Pubmed]
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  13. A comparison of nebulized budesonide, intramuscular dexamethasone, and placebo for moderately severe croup. Johnson, D.W., Jacobson, S., Edney, P.C., Hadfield, P., Mundy, M.E., Schuh, S. N. Engl. J. Med. (1998) [Pubmed]
  14. Brain glucose uptake and unawareness of hypoglycemia in patients with insulin-dependent diabetes mellitus. Boyle, P.J., Kempers, S.F., O'Connor, A.M., Nagy, R.J. N. Engl. J. Med. (1995) [Pubmed]
  15. The diagnosis and treatment of baroreflex failure. Robertson, D., Hollister, A.S., Biaggioni, I., Netterville, J.L., Mosqueda-Garcia, R., Robertson, R.M. N. Engl. J. Med. (1993) [Pubmed]
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  17. Increased synthesis of prostaglandin-E-like material by platelets from patients with diabetes mellitus. Halushka, P.V., Lurie, D., Colwell, J.A. N. Engl. J. Med. (1977) [Pubmed]
  18. Thromboxane biosynthesis and platelet function in type I diabetes mellitus. Alessandrini, P., McRae, J., Feman, S., FitzGerald, G.A. N. Engl. J. Med. (1988) [Pubmed]
  19. Platelet aggregation as a sign of septicemia in thermal injury. A prospective study. Cowan, D.H., Bowman, L.S., Fratianne, R.B., Ahmed, F. JAMA (1976) [Pubmed]
  20. Isolation and properties of the leukocytosis- and lymphocytosis-promoting factor of Bordetella pertussis. Morse, S.I., Morse, J.H. J. Exp. Med. (1976) [Pubmed]
  21. Concurrent morning increase in platelet aggregability and the risk of myocardial infarction and sudden cardiac death. Tofler, G.H., Brezinski, D., Schafer, A.I., Czeisler, C.A., Rutherford, J.D., Willich, S.N., Gleason, R.E., Williams, G.H., Muller, J.E. N. Engl. J. Med. (1987) [Pubmed]
  22. Psychological stress and metabolic control in patients with type I diabetes mellitus. Kemmer, F.W., Bisping, R., Steingrüber, H.J., Baar, H., Hardtmann, F., Schlaghecke, R., Berger, M. N. Engl. J. Med. (1986) [Pubmed]
  23. Platelet function in essential thrombocythemia. Decreased epinephrine responsiveness associated with a deficiency of platelet alpha-adrenergic receptors. Kaywin, P., McDonough, M., Insel, P.A., Shattil, S.J. N. Engl. J. Med. (1978) [Pubmed]
  24. Effects of somatostatin on hemostasis in baboons. Koerker, D.J., Harker, L.A., Goodner, C.J. N. Engl. J. Med. (1975) [Pubmed]
  25. A simple nonradioisotope technic for the determination of platelet life-span. Stuart, M.J., Murphy, S., Oski, F.A. N. Engl. J. Med. (1975) [Pubmed]
  26. Antibodies to purified insulin receptor have insulin-like activity. Jacobs, S., Chang, K.J., Cuatrecasas, P. Science (1978) [Pubmed]
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  28. Strain differences in rat brain epinephrine synthesis: regulation of alpha-adrenergic receptor number by epinephrine. Perry, B.D., Stolk, J.M., Vantini, G., Guchhait, R.B., U'Prichard, D.C. Science (1983) [Pubmed]
  29. Presynaptic regulation of the release of catecholamines. Langer, S.Z. Pharmacol. Rev. (1980) [Pubmed]
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  31. Identification of type I diabetic patients at increased risk for hypoglycemia during intensive therapy. White, N.H., Skor, D.A., Cryer, P.E., Levandoski, L.A., Bier, D.M., Santiago, J.V. N. Engl. J. Med. (1983) [Pubmed]
  32. Aspartame and susceptibility to headache. Schiffman, S.S., Buckley, C.E., Sampson, H.A., Massey, E.W., Baraniuk, J.N., Follett, J.V., Warwick, Z.S. N. Engl. J. Med. (1987) [Pubmed]
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  38. A soluble form of the Mer receptor tyrosine kinase inhibits macrophage clearance of apoptotic cells and platelet aggregation. Sather, S., Kenyon, K.D., Lefkowitz, J.B., Liang, X., Varnum, B.C., Henson, P.M., Graham, D.K. Blood (2007) [Pubmed]
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