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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Tandem repetition of the 5' mini-exon of variant surface glycoprotein genes: a multiple promoter for VSG gene transcription?

Activation of some variant surface glycoprotein (VSG) genes involves a duplicative transposition to an expression site, which completes the gene by addition of a mini-exon coding for the 5' 35 nucleotides of VSG mRNAs. Using a 22 nucleotide probe we have found some 200 copies of the mini-exon on a tandemly arranged 1.35 kb repetitive element. This repeat is highly conserved in three trypanosome species. The mini-exon on the repeat is flanked by a 5' splice site that resembles the consensus sequence. We have not found a single mini-exon within 10 kb of the transposed VSG gene exon in the expression site. We propose a model in which the arrays of mini-exon repeats function as a repetitive promoter for efficient transcription of VSG genes.[1]

References

  1. Tandem repetition of the 5' mini-exon of variant surface glycoprotein genes: a multiple promoter for VSG gene transcription? De Lange, T., Liu, A.Y., Van der Ploeg, L.H., Borst, P., Tromp, M.C., Van Boom, J.H. Cell (1983) [Pubmed]
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