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Kaidbey, K.H. et al.

Identification of topical photosensitizing agents in humans.

A method is described for the detection of topical photosensitizers in humans. Test agents were applied to the untanned midback under an occlusive dressing for 6 hr and then exposed to broad-spectrum radiation containing UV-A and visible wavelengths from a Xenon arc source. Well-known topical photosensitizers were readily identified. It was found that with certain poorly-penetrating substances, such as water-soluble dyes, applications to scarified skin were necessary to reveal phototoxic activity. In addition, these dyes were activated by wavelengths in the visible region of the spectrum.[1]

References

Identification of topical photosensitizing agents in humans. Kaidbey, K.H., Kligman, A.M. J. Invest. Dermatol. (1978) [Pubmed]

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