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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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RNA polymerase rifampicin resistance mutations in Escherichia coli: sequence changes and dominance.

Five recombinant plasmids, pBK2646, pBK611, pRC3, pRC4 and pRC5, carrying rpoB rifampicin-resistant RNA-polymerase genes were obtained. The sequence analysis of these plasmids revealed certain structural changes in the rpoB gene which specify corresponding alterations in the beta-subunit of RNA polymerase. Some functional properties of the corresponding mutant strains and their RNA polymerases have been investigated.[1]

References

  1. RNA polymerase rifampicin resistance mutations in Escherichia coli: sequence changes and dominance. Ovchinnikov, Y.A., Monastyrskaya, G.S., Guriev, S.O., Kalinina, N.F., Sverdlov, E.D., Gragerov, A.I., Bass, I.A., Kiver, I.F., Moiseyeva, E.P., Igumnov, V.N., Mindlin, S.Z., Nikiforov, V.G., Khesin, R.B. Mol. Gen. Genet. (1983) [Pubmed]
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