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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Methodologic approach to adverse events applied to bupropion clinical trials.

A strategy for identifying and classifying adverse events and for assessing their relationship to therapy and frequency of occurrence is presented. Data from clinical trials of bupropion (Wellbutrin), a novel antidepressant, are presented as an example. Bupropion was studied in four double-blind, placebo-controlled trials (N = 360) at dosages of 300-750 mg/day. The incidence and frequency of adverse events associated with bupropion were minimal, and correlated well with the known pharmacologic and clinical properties of this new antidepressant.[1]

References

  1. Methodologic approach to adverse events applied to bupropion clinical trials. Cato, A.E., Cook, L., Starbuck, R., Heatherington, D. The Journal of clinical psychiatry. (1983) [Pubmed]
 
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