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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Morphometric analysis of platelets in Bernard-Soulier syndrome: size and configuration in patients and carriers.

Quantitative ultrastructural morphometric analysis has been carried out on thin sections of platelets from two Bernard-Soulier sisters and their parents. Measurements were made for the major and minor axes, axial ratios, cross-sectional circumference and cross-sectional area. Platelets were collected either into CPD anticoagulant or directly into glutaraldehyde. The results confirm that Bernard-Soulier platelets are significantly larger than normals (p less than 0.05) in all the parameters mentioned and indicate (I) that the morphology of platelets from Bernard-Soulier patients is affected by the presence of anticoagulant, and (II) a more spherocytic configuration is characteristic of Bernard-Soulier disease both in patients and carriers.[1]

References

  1. Morphometric analysis of platelets in Bernard-Soulier syndrome: size and configuration in patients and carriers. McGill, M., Jamieson, G.A., Drouin, J., Cho, M.S., Rock, G.A. Thromb. Haemost. (1984) [Pubmed]
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