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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Induction of immunity to a human tumor marker by in vivo administration of anti-idiotypic antibodies in mice.

Anti-idiotypic antibodies are described that were raised against murine monoclonal antibody 8.2, an antibody specific for a human melanoma-associated cell surface marker called p97. The 8.2 idiotopes recognized by this anti-idiotypic antiserum are binding site-associated and are shared by other monoclonal anti-p97 antibodies with the same specificity as antibody 8. 2. Mice immunized with the anti-idiotype demonstrate delayed-type hypersensitivity reactions when challenged with melanoma ( p97-positive) tumor cells.[1]

References

  1. Induction of immunity to a human tumor marker by in vivo administration of anti-idiotypic antibodies in mice. Nepom, G.T., Nelson, K.A., Holbeck, S.L., Hellström, I., Hellström, K.E. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
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