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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

In vivo measurement of regional brain tissue pH using positron emission tomography.

Carbon-11-labeled dimethyloxazolidinedione ([11C]DMO) was injected intravenously into human subjects, and serial positron emission tomographic (PET) scans were obtained until brain-blood equilibration was achieved or could be accurately predicted from dynamic PET and 11C blood data. Knowledge of regional brain-blood partition coefficients for DMO, together with measurements of arterial blood hematocrit and pH, permitted the calculation of regional brain tissue and tumor pH (rpH). [11C]DMO PET rpH values were similar to rpH values derived from quantitative autoradiographic measurements of [14C]DMO concentrations in rat brain slices.[1]


  1. In vivo measurement of regional brain tissue pH using positron emission tomography. Rottenberg, D.A., Ginos, J.Z., Kearfott, K.J., Junck, L., Bigner, D.D. Ann. Neurol. (1984) [Pubmed]
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