The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

dimethadione     5,5-dimethyl-1,3-oxazolidine- 2,4-dione

Synonyms: Propazone, Eupractone, Dimetadiona, Dimetadione, Dimethadion, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Dimethyloxazolidinedione


High impact information on Dimethyloxazolidinedione


Chemical compound and disease context of Dimethyloxazolidinedione


Biological context of Dimethyloxazolidinedione


Anatomical context of Dimethyloxazolidinedione


Associations of Dimethyloxazolidinedione with other chemical compounds


Gene context of Dimethyloxazolidinedione


Analytical, diagnostic and therapeutic context of Dimethyloxazolidinedione


  1. The state of energization of the membrane of Escherichia coli as affected by physiological conditions and colicin K. Brewer, G.J. Biochemistry (1976) [Pubmed]
  2. Pancreatic excretion test and barrier hypothesis in progression of chronic pancreatitis. Noda, A., Hayakawa, T., Horiguchi, Y., Naruse, S., Iinuma, Y. Am. J. Gastroenterol. (1978) [Pubmed]
  3. Embryonic arrhythmia by inhibition of HERG channels: a common hypoxia-related teratogenic mechanism for antiepileptic drugs? Azarbayjani, F., Danielsson, B.R. Epilepsia (2002) [Pubmed]
  4. Proton motive force and Na+/H+ antiport in a moderate halophile. Hamaide, F., Kushner, D.J., Sprott, G.D. J. Bacteriol. (1983) [Pubmed]
  5. Central nervous system pH in uremia and the effects of hemodialysis. Arieff, A.I., Guisado, R., Massry, S.G., Lazarowitz, V.C. J. Clin. Invest. (1976) [Pubmed]
  6. Extracellular Na+ and initiation of DNA synthesis: role of intracellular pH and K+. Burns, C.P., Rozengurt, E. J. Cell Biol. (1984) [Pubmed]
  7. Na+/H+ antiport in Swiss 3T3 cells: mitogenic stimulation leads to cytoplasmic alkalinization. Schuldiner, S., Rozengurt, E. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  8. Cytoplasmic Ca2+ and H+ concentrations determine cell fate in Dictyostelium discoideum. Kubohara, Y., Okamoto, K. FASEB J. (1994) [Pubmed]
  9. In vivo measurement of regional brain tissue pH using positron emission tomography. Rottenberg, D.A., Ginos, J.Z., Kearfott, K.J., Junck, L., Bigner, D.D. Ann. Neurol. (1984) [Pubmed]
  10. Trimethadione tolerance test for one-point estimation of the severity of liver damage in cirrhotic patients. Tanaka, E., Ishikawa, A., Fukao, K., Tsuji, K., Osada, A., Yamamoto, Y., Adachi, S., Takase, Y., Abei, M., Iwasaki, Y. International journal of clinical pharmacology, therapy, and toxicology. (1991) [Pubmed]
  11. Electrochemical proton gradient across the cell membrane of Halobacterium halobium: comparison of the light-induced increase with the increase of intracellular adenosine triphosphate under steady-state illumination. Michel, H., Oesterhelt, D. Biochemistry (1980) [Pubmed]
  12. Acidification of intracellular pH in bovine spermatozoa suppresses motility and extends viable life. Jones, J.M., Bavister, B.D. J. Androl. (2000) [Pubmed]
  13. Abnormalities in ureter and kidney development in mice given acetazolamide-amiloride or dimethadione (DMO) during embryogenesis. Miller, T.A., Scott, W.J. Teratology (1992) [Pubmed]
  14. The kinetics of efflux of 5,5-dimethyl-2,4-oxazolidinedione (DMO) from the myocardium. Poole-Wilson, P.A. Clinical science and molecular medicine. (1976) [Pubmed]
  15. Effect of hyperglycemia on blood flow, pH, and response to hyperthermia (42 degrees) of the Yoshida sarcoma in the rat. Calderwood, S.K., Dickson, J.A. Cancer Res. (1980) [Pubmed]
  16. Matrix magnesium and the permeability of heart mitochondria to potassium ion. Jung, D.W., Brierley, G.P. J. Biol. Chem. (1986) [Pubmed]
  17. Intracellular pH increase driven by an Na+/H+ exchanger upon activation of surf clam oocytes. Dubé, F., Eckberg, W.R. Dev. Biol. (1997) [Pubmed]
  18. The effect of insulin on plasma-membrane and mitochondrial-membrane potentials in isolated fat-cells. Davis, R.J., Brand, M.D., Martin, B.R. Biochem. J. (1981) [Pubmed]
  19. pH-dependency of iodothyronine metabolism in isolated perfused rat liver. Köhrle, J., Müller, M.J., Ködding, R., Seitz, H.J., Hesch, R.D. Biochem. J. (1982) [Pubmed]
  20. Electrochemical proton gradient across the cell membrane of Halobacterium halobium: effect of N,N'-dicyclohexylcarbodiimide, relation to intracellular adenosine triphosphate, adenosine diphosphate, and phosphate concentration, and influence of the potassium gradient. Michel, H., Oesterhelt, D. Biochemistry (1980) [Pubmed]
  21. Intracellular pH and catecholamine synthesis in cultured bovine adrenal medullary cells: effect of extracellular Na+ removal. Yanagihara, N., Yokota, K., Wada, A., Izumi, F. J. Neurochem. (1987) [Pubmed]
  22. Intracellular pH and distribution of weak acids across cell membranes. A study of D- and L-lactate and of DMO in rat diaphragm. Roos, A. J. Physiol. (Lond.) (1975) [Pubmed]
  23. Comparison of the effects of trimethadione and its primary metabolite dimethadione on neuromuscular function and the effects of altered pH on the actions of dimethadione. Alderdice, M.T., McMillan, J.E. J. Pharmacol. Exp. Ther. (1982) [Pubmed]
  24. Induction of cytochrome P-450 and related drug-oxidizing activities in muscone (3-methylcyclopentadecanone)-treated rats. Tanaka, E., Kurata, N., Kohno, M., Yoshida, T., Kuroiwa, Y. Biochem. Pharmacol. (1987) [Pubmed]
  25. Trimethadione metabolism, a useful indicator for assessing hepatic drug-oxidizing capacity. Nakamura, M., Tanaka, E., Misawa, S., Shimada, T., Imaoka, S., Funae, Y. Biochem. Pharmacol. (1994) [Pubmed]
  26. Interleukin 2 induces a rapid increase in intracellular pH through activation of a Na+/H+ antiport. Cytoplasmic alkalinization is not required for lymphocyte proliferation. Mills, G.B., Cragoe, E.J., Gelfand, E.W., Grinstein, S. J. Biol. Chem. (1985) [Pubmed]
  27. Inhibition of trimethadione and dimethadione teratogenicity by the cyclooxygenase inhibitor acetylsalicylic acid: a unifying hypothesis for the teratologic effects of hydantoin anticonvulsants and structurally related compounds. Wells, P.G., Nagai, M.K., Greco, G.S. Toxicol. Appl. Pharmacol. (1989) [Pubmed]
  28. Intracellular pH of brain: alterations in acute respiratory acidosis and alkalosis. Arieff, A.I., Kerian, A., Massry, S.G., DeLima, J. Am. J. Physiol. (1976) [Pubmed]
  29. Lithium movements in resting and chemotactic factor-activated human neutrophils. Simchowitz, L. Am. J. Physiol. (1988) [Pubmed]
  30. In vivo myocardial cell pH in the dog. Response to ischemia and infusion of alkali. Effros, R.M., Haider, B., Ettinger, P.O., Ahmed Sultan, S., Oldewurtel, H.A., Marold, K., Regan, T.J. J. Clin. Invest. (1975) [Pubmed]
  31. In vivo uptake of [3H]nimodipine in focal cerebral ischemia: modulation by hyperglycemia. Osuga, S., Hogan, M.J. J. Cereb. Blood Flow Metab. (1997) [Pubmed]
  32. Mechanisms regulating intracellular pH in sea urchin eggs. Payan, P., Girard, J.P., Ciapa, B. Dev. Biol. (1983) [Pubmed]
  33. Influence of partial hepatectomy in dogs on trimethadione metabolism and microsomal monooxygenases. Tanaka, E., Osada, A., Ishikawa, A., Nakamura, T., Momose, Y., Mikami, T., Fukao, K., Horie, T. Xenobiotica (1995) [Pubmed]
  34. Estimating intracellular pH in developing rodent embryos using a computer imaging technique: changes in embryonic pH and proliferation rates following maternal treatment with acetazolamide. Schreiner, C.M., Collins, M.D., Scott, W.J., Vorhees, C.V., Colvin, J., McCandless, D. Teratology (1995) [Pubmed]
WikiGenes - Universities