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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Aroyl- and arylisoquinolineacetic acids as antiinflammatory agents.

A series of 1-benzoyl- and 1-phenylisoquinolineacetic acid derivatives was prepared and tested for antiinflammatory activity. The most potent compound synthesized, 1-(4-chlorophenyl)-3-isoquinolineacetamide, was as active as phenylbutazone in the Evans blue carrageenan-induced pleural effusion assay but inactive in the adjuvant-induced arthritis model of chronic inflammation.[1]

References

  1. Aroyl- and arylisoquinolineacetic acids as antiinflammatory agents. Walsh, D.A., Sancilio, L.F., Reese, D.L. J. Med. Chem. (1978) [Pubmed]
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