Disease relevance of Pleural Effusion

• Concurrent assays of plasma and pleural-effusion levels of carcinoembryonic antigen in the diagnosis of pulmonary disease [1].
• Fatty liver and pleural effusion with ibuprofen therapy [2].
• Features included two episodes of disease, dual or sequential infections with Legionella pneumophila and other pathogens; transient deafness with erythromycin therapy, and Legionnaires' disease with a pleural effusion but no pulmonary infiltrate [3].
• TG mice had higher incidences of premature death and critical illness due to heart failure (75% versus 23%), pleural effusion (81% versus 45%), and left atrial thrombosis (81% versus 36%, all P<0.05) [4].
• Pathological examination of affected animals revealed a globular dilated heart, bilateral pleural effusions, myocyte apoptosis, and transmural myocarditis in both the right and left ventricular free walls, septum, and atrial chambers [5].

High impact information on Pleural Effusion

• After exposure to hyperoxia for 52 h, pleural effusion volume, pulmonary artery pressure, total pulmonary resistance, and lung morphologic damage were decreased in those rats given TNF/C and IL-1 as compared with saline-injected rats [6].
• Intravenous injection of control liposomes along with catalase and superoxide dismutase in the suspending buffer decreased the mean pleural effusion volume 89% and had no significant effect on survival time [7].
• Decreased heat-labile opsonic activity and complement levels associated with evidence of C3 breakdown products in infected pleural effusions [8].
• Isotretinoin and eosinophilic pleural effusion [9].
• Carcinoembryonic antigen in pleural effusions [10].

Chemical compound and disease context of Pleural Effusion

• Letter: Pleural effusions after practolol [11].
• The light microscopic histochemical studies suggested the presence of Phi bodies and rods both in the formalin-fixed tumor and in the cells derived from the subsequent pleural effusion; this was confirmed by electron microscopy, which demonstrated the peridicity of the crystalline rod substructure [12].
• PATIENTS AND METHODS: Forty-three patients who had stage IIIB NSCLC with pleural effusion or stage IV NSCLC and had received no prior therapy received bexarotene in combination with cisplatin (100 mg/m2) and vinorelbine (alternating doses of 30 mg/m2 and 15 mg/m2) [13].
• Immune complexes isolated from pleural effusions of lung carcinomas were dissociated by ion exchange chromatography in the presence of 8 M urea [14].
• The arachidonic acid lipoxygenase products 15-hydroxyeicosatetraenoic acid, 12-hydroxyeicosatetraenoic acid, and 5-hydroxyeicosatetraenoic acid and the arachidonic acid cyclooxygenase product prostaglandin E2 were quantitated in 11 malignant and 10 nonmalignant peritoneal and pleural effusions [15].

Biological context of Pleural Effusion

• PATIENTS AND METHODS: We performed reverse transcription polymerase chain reaction (RT-PCR) analysis of SP-A gene transcript in the cells of pleural effusion from 42 consecutive patients with pleural effusion, including 7 patients with primary lung adenocarcinoma before their treatments [16].
• The pharmacokinetics of ceftriaxone were studied for seven patients with pleural effusion of various etiologies [17].
• The purpose of this study was to describe changes in initial distribution volume of glucose, plasma volume determined by the indocyanine green dilution method (PV-ICG), and thoracic fluid content by thoracic electrical bioimpedance in patients with or without apparent thoracic fluid accumulation in the absence of pleural effusion [18].
• Detection of K-ras point mutations in the supernatants of peritoneal and pleural effusions for diagnosis complementary to cytologic examination [19].
• The decrease in NK cell subpopulations with elevated IL-10 and minimal IL-12 concentration in neoplastic pleural effusion would suggest the usage of IL-12 or antibody of IL-10 to improve local cellular immunity [20].

Anatomical context of Pleural Effusion

• Hepatitis B antigen in pleural effusion and ascitic fluids [21].
• Two small cell lung cancer (SCLC) cell lines were established from pericardial and pleural effusions of a patient with histopathologically proven SCLC of the oat cell type [22].
• The clinical manifestations of tuberculous pleuritis, such as fever, exudative pleural effusion, and tissue necrosis, may be due to the effects of elevated local TNF concentrations, produced in response to mycobacterial cell wall components [23].
• By injecting technetium Tc 99m albumin aggregated into the peritoneal cavity, shunt patency and rapid flow into the pleural effusion were demonstrated [24].
• To explore the possible role of pleural macrophages in the regulation of IL-8, pleural effusion cells were treated with culture supernatants from stimulated pleural macrophages [25].

Gene context of Pleural Effusion

• No correlation was found between tumour vessel density and either serum (r=0.26; p=0.42) or pleural effusion (r=0.35; p=0.26) VEGF levels [26].
• Interleukin-8 and markers of neutrophil degranulation in pleural effusions [27].
• In addition, a correlation was observed between the levels of TGF-beta in pleural effusion and in BALF [28].
• The levels of IL-6 and sTNFRI and sTNFRII in pleural effusion were higher than in plasma, whereas the levels of IL-1ra and sIL-6R were higher in plasma [28].
• In this study, we sought to analyze the expression of MMP and TIMP isoforms in pleural effusions from 88 patients [29].

Analytical, diagnostic and therapeutic context of Pleural Effusion

• Successful use of tetracycline pleurodesis to treat massive pleural effusion secondary to systemic lupus erythematosus [30].
• Dramatically greater increases in pleural effusions and bronchoalveolar lavage protein concentrations in response to hyperoxia were observed in the Fischer-344 rats than in the Sprague-Dawley rats (p < .05 at both 48 and 60 h for both measurements) [31].
• We isolated galactosyltransferase (EC 2.4.1.22) from pleural effusions of a lung cancer patient and a patient with cirrhosis by precipitation with ammonium sulfate, followed by gel filtration on Sepharose 6B, and affinity chromatography on columns of alpha-lactalbumin-agarose and protein A-Sepharose [32].
• Two measures of tumor burden, serum lactic dehydrogenase and, in a subset of patients, interleukin-2-receptor levels, were significantly higher in patients with pleural effusion (p = 0.002 and p = 0.05, respectively) [33].
• Accordingly, exhaustive aspiration of radiologically verified pleural effusion before starting chemotherapy in patients with SCLC is recommended [34].

References