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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Effect of coal tar on cutaneous aryl hydrocarbon hydroxylase induction and anthralin irritancy.

The inflammatory dose-response to topical anthralin and whole skin aryl hydrocarbon hydroxylase ( AHH) activity were measured before and 24 h after application of a coal tar solution to the uninvolved skin of patients with psoriasis. The inflammatory response to anthralin decreased and total AHH activity increased after the tar treatment. A possible explanation is that anthralin or an irritant product is metabolized by AHH activity in the skin. Induction of AHH by coal tar increases its removal and reduces anthralin irritancy.[1]

References

  1. Effect of coal tar on cutaneous aryl hydrocarbon hydroxylase induction and anthralin irritancy. Lawrence, C.M., Finnen, M.J., Shuster, S. Br. J. Dermatol. (1984) [Pubmed]
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