Determination of 1-methylimidazole-4-acetic acid in brain tissue from rat and mouse.
The concentration of the histamine metabolite 1-methylimidazole-4-acetic acid was determined in brain tissue from rat and mouse with a gas chromatographic-mass spectrometric method. Mouse brain contained 1.7-3.2 nmol/g, depending on the strain. The concentration in cerebrum from Sprague-Dawley rats was 1.2 nmol/g, whereas cerebellum contained 0.24 nmol/g. The concentration of tele-methylhistamine in mouse brain was 1.4-2.2 nmol/g. The concentration of 1-methylimidazole-4-acetic acid in rat brain after death did not change significantly during 2 h at room temperature.[1]References
- Determination of 1-methylimidazole-4-acetic acid in brain tissue from rat and mouse. Swahn, C.G. J. Neurochem. (1984) [Pubmed]
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