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Disease relevance of Telencephalon


Psychiatry related information on Telencephalon


High impact information on Telencephalon

  • In this issue of Cell, work by López-Bendito et al.(2006) reveals that tangentially migrating cells within the ventral telencephalon are essential for axonal navigation between the thalamus and the neocortex, a process apparently mediated by Neuregulin-1/ErbB4 short- and long-range signaling [11].
  • Axons projecting from the olfactory bulb to the telencephalon are guided by a repulsive activity in the septum [12].
  • The majority of Casp9 knockout mice die perinatally with a markedly enlarged and malformed cerebrum caused by reduced apoptosis during brain development [13].
  • Here we report that the secreted protein Slit repels neuronal precursors migrating from the anterior subventricular zone in the telencephalon to the olfactory bulb [14].
  • Patterning of the anterolateral neural plate (telencephalon) may be regulated by FGF8 produced in the anterior neural ridge [15].

Chemical compound and disease context of Telencephalon


Biological context of Telencephalon


Anatomical context of Telencephalon


Associations of Telencephalon with chemical compounds

  • Transgenic FVB/N mice overexpressing human (Hu) or mouse (Mo) Alzheimer amyloid precursor protein (APP695) die early and develop a CNS disorder that includes neophobia and impaired spatial alternation, with diminished glucose utilization and astrogliosis mainly in the cerebrum [31].
  • Telencephalin (TLN) is a 130 kd glycoprotein expressed exclusively in neurons of the telencephalon, the most rostral brain segment [32].
  • The presence and distribution of calsequestrin (CS), Ca2+ pump, and inositol 1,4,5-trisphosphate (IP3) receptor were investigated biochemically and immunologically in microsomal (P3) fractions isolated from chicken cerebrum and cerebellum [33].
  • On the basis of two criteria, our studies demonstrate that the 51,000-Mr protein marker for postsynaptic densities is virtually absent in cerebellum, First, it is present in negligible amounts in deoxycholate-insoluble fractions from cerebellum but abundant in parallel fractions from cerebrum [34].
  • In this study we have characterized vesicular GABA and glycine uptakes in the cerebrum and spinal cord, respectively [35].

Gene context of Telencephalon


Analytical, diagnostic and therapeutic context of Telencephalon


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  17. Astrocyte metabolism is disturbed in the early development of experimental hydrocephalus. Kondziella, D., Qu, H., Lüdemann, W., Brinker, T., Sletvold, O., Sonnewald, U. J. Neurochem. (2003) [Pubmed]
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  32. An ICAM-related neuronal glycoprotein, telencephalin, with brain segment-specific expression. Yoshihara, Y., Oka, S., Nemoto, Y., Watanabe, Y., Nagata, S., Kagamiyama, H., Mori, K. Neuron (1994) [Pubmed]
  33. Calsequestrin, a component of the inositol 1,4,5-trisphosphate-sensitive Ca2+ store of chicken cerebellum. Volpe, P., Alderson-Lang, B.H., Madeddu, L., Damiani, E., Collins, J.H., Margreth, A. Neuron (1990) [Pubmed]
  34. Putative 51,000-Mr protein marker for postsynaptic densities is virtually absent in cerebellum. Flanagan, S.D., Yost, B., Crawford, G. J. Cell Biol. (1982) [Pubmed]
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