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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

THIP: a single-blind controlled trial in patients with epilepsy.

In an early phase-2 study, THIP (4,5,6,7-tetrahydroisoxazolo(5,4-c)pyridin-3-ol) was investigated in a single-blind controlled trial comprising 9 outpatients suffering from epilepsy. THIP was added to the concomitant antiepileptic treatment with increasing doses (15 to 120 mg/day) based on therapeutic effect or side-effects. The blood levels of concomitant therapy were kept constant. No significant difference was established between the number of seizures during treatment with maximal doses of THIP and placebo. A trend was observed for lower seizure frequency during a period on submaximal dose of THIP.[1]


  1. THIP: a single-blind controlled trial in patients with epilepsy. Petersen, H.R., Jensen, I., Dam, M. Acta neurologica Scandinavica. (1983) [Pubmed]
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