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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
 
 
 
 

Determination of fluoxetine and norfluoxetine in plasma by gas chromatography with electron-capture detection.

This gas-chromatographic method for assay of fluoxetine and norfluoxetine in human plasma involves extraction of the drugs and use of a 63Ni electron-capture detector. The linear range of detection is 25 to 800 micrograms/L for each drug. Overall precision (CV) in the concentration range of 10 to 100 micrograms/L for both drugs was approximately 10%. Accuracy (relative error) in the same concentration range was approximately +10%. None of the commonly prescribed antidepressants or tranquilizers that we tested interfere with the assay.[1]

References

  1. Determination of fluoxetine and norfluoxetine in plasma by gas chromatography with electron-capture detection. Nash, J.F., Bopp, R.J., Carmichael, R.H., Farid, K.Z., Lemberger, L. Clin. Chem. (1982) [Pubmed]
 
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